المؤلفون: Megan E. Capozzi, Caslin A. Gilroy, Anastasia K. Varanko, David A. D'Alessio, Jenny Tong, Ashutosh Chilkoti, Jonathan E. Campbell

المصدر: Science Advances

مصطلحات موضوعية: Agonist, endocrine system, FGF21, Combination therapy, medicine.drug_class, 030209 endocrinology & metabolism, Type 2 diabetes, Pharmacology, Glucagon-Like Peptide-1 Receptor, Diabetes Mellitus, Experimental, Mice, 03 medical and health sciences, Engineering, 0302 clinical medicine, Glucagon-Like Peptide 1, Weight loss, medicine, Animals, Humans, Health and Medicine, Obesity, Research Articles, 030304 developmental biology, Glycemic, 0303 health sciences, Multidisciplinary, business.industry, SciAdv r-articles, medicine.disease, Fibroblast Growth Factors, Diabetes Mellitus, Type 2, Delayed-Action Preparations, Hyperglycemia, medicine.symptom, Peptides, business, Linker, hormones, hormone substitutes, and hormone antagonists, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::149abe5ec52a4b0d67342e0c03e89e88Test
https://doi.org/10.1126/sciadv.aaz9890Test

المؤلفون: Brandon C. P. Clavette, Xiaoshan Min, Joanne Lin, Elizabeth A. Killion, Robert J.M. Kurzeja, David Lloyd, Liying Deng, Zhulun Wang, Clarence Hale, Christopher Murawsky, Stone D.-H. Shi, Murielle M. Véniant, Jinghong Wang, James B. Rottman, Christina Abbott, Todd Hager, Lu Shu Chen, Junming Yie, Ian Foltz, Qing Chen, Stephen A. Thibault, Darren L. Bates, Renee Komorowski, Larissa Atangan, Glenn Sivits, Tina Meng

المصدر: Science Translational Medicine. 10

مصطلحات موضوعية: Primates, 0301 basic medicine, endocrine system, medicine.medical_specialty, Recombinant Fusion Proteins, Glucagon-Like Peptides, Mice, Obese, Genome-wide association study, Gastric Inhibitory Polypeptide, Weight Gain, Antibodies, Glucagon-Like Peptide-1 Receptor, Receptors, Gastrointestinal Hormone, 03 medical and health sciences, 0302 clinical medicine, Weight loss, Insulin-Secreting Cells, Internal medicine, Weight Loss, Conditional gene knockout, Adipocytes, Animals, Humans, Medicine, Obesity, Receptor, Respiratory exchange ratio, biology, business.industry, Respiration, Feeding Behavior, General Medicine, Liraglutide, medicine.disease, Diet, Immunoglobulin Fc Fragments, 030104 developmental biology, Endocrinology, 030220 oncology & carcinogenesis, Knockout mouse, biology.protein, Drug Therapy, Combination, medicine.symptom, Antibody, business, hormones, hormone substitutes, and hormone antagonists

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4219a5cd6927493203264b2541e2f88bTest
https://doi.org/10.1126/scitranslmed.aat3392Test

المؤلفون: Kim G. Madsen, Flemming L. Søndergaard, Jonas Ahnfelt-Rønne, Andrew J. Benie, Simon Bjerregaard, Jeanett Borregaard, Tine A. Bækdal, Betty Lomstein Pedersen, Susanne Schéele, Charles Pyke, Marie-Louise Hartoft-Nielsen, Stephen T. Buckley, Tomas Alanentalo, Rikke Bjerring Skyggebjerg, Rikke Kaae Kirk, Lotte Bjerre Knudsen, Stine J. Maarbjerg, Holger M. Strauss, Andreas Vegge, Csaba Fekete, Erzsébet Farkas, Per-Olof Wahlund

المصدر: Science Translational Medicine. 10

مصطلحات موضوعية: Adult, Male, Absorption (pharmacology), Time Factors, Adolescent, Glucagon-Like Peptides, Administration, Oral, 02 engineering and technology, Pharmacology, 030226 pharmacology & pharmacy, Glucagon-Like Peptide-1 Receptor, Intestinal absorption, Young Adult, 03 medical and health sciences, Dogs, 0302 clinical medicine, Glucagon-Like Peptide 1, Oral administration, Animals, Humans, Transcellular, Glucagon-like peptide 1 receptor, Aged, Tight junction, Chemistry, Semaglutide, Cell Membrane, Stomach, Proteolytic enzymes, Epithelial Cells, General Medicine, Hydrogen-Ion Concentration, Middle Aged, 021001 nanoscience & nanotechnology, Rats, Intestinal Absorption, Gastric Mucosa, 0210 nano-technology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da23aec5d09c52d95e43b0ca9e999cdbTest
https://doi.org/10.1126/scitranslmed.aar7047Test

المؤلفون: James L Mitchell, Rigmor Jensen, Maria Uldall, Alexandra J Sinclair, Snorre Malm Hagen, David J. Hodson, Hannah Botfield, Ana Maria Gonzalez, Connar Westgate

المصدر: Science Translational Medicine. 9

مصطلحات موضوعية: 0301 basic medicine, Agonist, endocrine system, medicine.medical_specialty, Consciousness, Intracranial Pressure, medicine.drug_class, Glucagon-Like Peptide-1 Receptor, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Cerebrospinal fluid, Internal medicine, Cyclic AMP, medicine, Animals, Humans, RNA, Messenger, Receptor, Glucagon-like peptide 1 receptor, Intracranial pressure, Kidney, Venoms, business.industry, digestive, oral, and skin physiology, Antagonist, General Medicine, 3. Good health, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, Postmortem Changes, Choroid Plexus, Exenatide, Female, Choroid plexus, Sodium-Potassium-Exchanging ATPase, Peptides, business, hormones, hormone substitutes, and hormone antagonists, 030217 neurology & neurosurgery, Hydrocephalus

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87911b2ba2bdba79994b9b14a26bd5fbTest
https://doi.org/10.1126/scitranslmed.aan0972Test

المؤلفون: Scott, Robert A, Freitag, Daniel F, Li, Li, Chu, Audrey Y, Surendran, Praveen, Young, Robin, Grarup, Niels, Stancáková, Alena, Chen, Yuning, Varga, Tibor V, Yaghootkar, Hanieh, Luan, Jian'an, Zhao, Jing Hua, Willems, Sara M, Wessel, Jennifer, Wang, Shuai, Maruthur, Nisa, Michailidou, Kyriaki, Pirie, Ailith, van der Lee, Sven J, Gillson, Christopher, Al Olama, Ali Amin, Amouyel, Philippe, Arriola, Larraitz, Arveiler, Dominique, Aviles-Olmos, Iciar, Balkau, Beverley, Barricarte, Aurelio, Barroso, Inês, Garcia, Sara Benlloch, Bis, Joshua C, Blankenberg, Stefan, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Borecki, Ingrid B, Bork-Jensen, Jette, Bowden, Sarah, Caldas, Carlos, Caslake, Muriel, CVD50 consortium, Cupples, L Adrienne, Cruchaga, Carlos, Czajkowski, Jacek, den Hoed, Marcel, Dunn, Janet A, Earl, Helena M, Ehret, Georg B, Ferrannini, Ele, Ferrieres, Jean, Foltynie, Thomas, Ford, Ian, Forouhi, Nita G, Gianfagna, Francesco, Gonzalez, Carlos, Grioni, Sara, Hiller, Louise, Jansson, Jan-Håkan, Jørgensen, Marit E, Jukema, J Wouter, Kaaks, Rudolf, Kee, Frank, Kerrison, Nicola D, Key, Timothy J, Kontto, Jukka, Kote-Jarai, Zsofia, Kraja, Aldi T, Kuulasmaa, Kari, Kuusisto, Johanna, Linneberg, Allan, Liu, Chunyu, Marenne, Gaëlle, Mohlke, Karen L, Morris, Andrew P, Muir, Kenneth, Müller-Nurasyid, Martina, Munroe, Patricia B, Navarro, Carmen, Nielsen, Sune F, Nilsson, Peter M, Nordestgaard, Børge G, Packard, Chris J, Palli, Domenico, Panico, Salvatore, Peloso, Gina M, Perola, Markus, Peters, Annette, Poole, Christopher J, Quirós, J Ramón, Rolandsson, Olov, Sacerdote, Carlotta, Salomaa, Veikko, Sánchez, María-José, Sattar, Naveed, Sharp, Stephen J, Sims, Rebecca, Slimani, Nadia, Smith, Jennifer A, Thompson, Deborah J, Trompet, Stella, Tumino, Rosario, van der A, Daphne L, van der Schouw, Yvonne T, Virtamo, Jarmo, Walker, Mark, Walter, Klaudia, GERAD_EC Consortium, Neurology Working Group of the Cohorts for Heart, Aging Research in Genomic Epidemiology (CHARGE), Alzheimer’s Disease Genetics Consortium, Pancreatic Cancer Cohort Consortium, European Prospective Investigation into Cancer and Nutrition–Cardiovascular Disease (EPIC-CVD), EPIC-InterAct, Abraham, Jean E, Amundadottir, Laufey T, Aponte, Jennifer L, Butterworth, Adam S, Dupuis, Josée, Easton, Douglas F, Eeles, Rosalind A, Erdmann, Jeanette, Franks, Paul W, Frayling, Timothy M, Hansen, Torben, Howson, Joanna MM, Jørgensen, Torben, Kooner, Jaspal, Laakso, Markku, Langenberg, Claudia, McCarthy, Mark I, Pankow, James S, Pedersen, Oluf, Riboli, Elio, Rotter, Jerome I, Saleheen, Danish, Samani, Nilesh J, Schunkert, Heribert, Vollenweider, Peter, O'Rahilly, Stephen, CHARGE consortium, CHD Exome+ Consortium, CARDIOGRAM Exome Consortium, Deloukas, Panos, Danesh, John, Goodarzi, Mark O, Kathiresan, Sekar, Meigs, James B, Ehm, Margaret G, Wareham, Nicholas J, Waterworth, Dawn M

مصطلحات موضوعية: Alleles, Coronary Disease, Diabetes Mellitus, Type 2, Dipeptidyl Peptidase 4, Genotype, Glucagon-Like Peptide-1 Receptor, Humans, Obesity, Receptor, Cannabinoid, CB2, Serotonin, 5-HT2C, Receptors, Somatostatin, Sodium-Glucose Transporter 1

وصف الملف: application/pdf

العلاقة: https://www.repository.cam.ac.uk/handle/1810/256264Test

الإتاحة: https://doi.org/10.17863/CAM.205Test
https://www.repository.cam.ac.uk/handle/1810/256264Test

المؤلفون: Oleg G. Chepurny, George G. Holz

المصدر: Science's STKE. 2005

مصطلحات موضوعية: medicine.medical_specialty, Insulin Receptor Substrate Proteins, medicine.medical_treatment, FOXO1, Biology, Models, Biological, Article, Glucagon-Like Peptide-1 Receptor, Diabetes Mellitus, Experimental, Islets of Langerhans, Mice, Glucagon-Like Peptide 1, Internal medicine, Heterotrimeric G protein, Insulin Secretion, Receptors, Glucagon, medicine, Animals, Humans, Insulin, Transcription factor, Protein kinase B, G protein-coupled receptor, Homeodomain Proteins, Mice, Knockout, Hyperplasia, Intracellular Signaling Peptides and Proteins, General Medicine, Phosphoproteins, Rats, Endocrinology, Diabetes Mellitus, Type 2, Trans-Activators, Signal transduction, Secretory Rate, Proto-Oncogene Proteins c-akt, hormones, hormone substitutes, and hormone antagonists, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f629a99e85ea0160f4520c729a335271Test
https://doi.org/10.1126/stke.2682005pe2Test

المؤلفون: Scott, Robert A, Freitag, Daniel F, Li, Li, Chu, Audrey Y, Surendran, Praveen, Young, Robin, Grarup, Niels, Stancáková, Alena, Chen, Yuning, Varga, Tibor V, Yaghootkar, Hanieh, Luan, Jian'an, Zhao, Jing Hua, Willems, Sara M, Wessel, Jennifer, Wang, Shuai, Maruthur, Nisa, Michailidou, Kyriaki, Pirie, Ailith, Van Der Lee, Sven J, Gillson, Christopher, Al Olama, Ali Amin, Amouyel, Philippe, Arriola, Larraitz, Arveiler, Dominique, Aviles-Olmos, Iciar, Balkau, Beverley, Barricarte, Aurelio, Barroso, Inês, Garcia, Sara Benlloch, Bis, Joshua C, Blankenberg, Stefan, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Borecki, Ingrid B, Bork-Jensen, Jette, Bowden, Sarah, Caldas, Carlos, Caslake, Muriel, CVD50 Consortium, Cupples, L Adrienne, Cruchaga, Carlos, Czajkowski, Jacek, Den Hoed, Marcel, Dunn, Janet A, Earl, Helena M, Ehret, Georg B, Ferrannini, Ele, Ferrieres, Jean, Foltynie, Thomas, Ford, Ian, Forouhi, Nita G, Gianfagna, Francesco, Gonzalez, Carlos, Grioni, Sara, Hiller, Louise, Jansson, Jan-Håkan, Jørgensen, Marit E, Jukema, J Wouter, Kaaks, Rudolf, Kee, Frank, Kerrison, Nicola D, Key, Timothy J, Kontto, Jukka, Kote-Jarai, Zsofia, Kraja, Aldi T, Kuulasmaa, Kari, Kuusisto, Johanna, Linneberg, Allan, Liu, Chunyu, Marenne, Gaëlle, Mohlke, Karen L, Morris, Andrew P, Muir, Kenneth, Müller-Nurasyid, Martina, Munroe, Patricia B, Navarro, Carmen, Nielsen, Sune F, Nilsson, Peter M, Nordestgaard, Børge G, Packard, Chris J, Palli, Domenico, Panico, Salvatore, Peloso, Gina M, Perola, Markus, Peters, Annette, Poole, Christopher J, Quirós, J Ramón, Rolandsson, Olov, Sacerdote, Carlotta, Salomaa, Veikko, Sánchez, María-José, Sattar, Naveed, Sharp, Stephen J, Sims, Rebecca, Slimani, Nadia, Smith, Jennifer A, Thompson, Deborah J, Trompet, Stella, Tumino, Rosario, Van Der A, Daphne L, Van Der Schouw, Yvonne T, Virtamo, Jarmo, Walker, Mark, Walter, Klaudia, GERAD_EC Consortium, Neurology Working Group Of The Cohorts For Heart, Aging Research In Genomic Epidemiology (CHARGE), Alzheimer’s Disease Genetics Consortium, Pancreatic Cancer Cohort Consortium, European Prospective Investigation Into Cancer And Nutrition–Cardiovascular Disease (EPIC-CVD), EPIC-InterAct, Abraham, Jean E, Amundadottir, Laufey T, Aponte, Jennifer L, Butterworth, Adam S, Dupuis, Josée, Easton, Douglas F, Eeles, Rosalind A, Erdmann, Jeanette, Franks, Paul W, Frayling, Timothy M, Hansen, Torben, Howson, Joanna MM, Jørgensen, Torben, Kooner, Jaspal, Laakso, Markku, Langenberg, Claudia, McCarthy, Mark I, Pankow, James S, Pedersen, Oluf, Riboli, Elio, Rotter, Jerome I, Saleheen, Danish, Samani, Nilesh J, Schunkert, Heribert, Vollenweider, Peter, O'Rahilly, Stephen, CHARGE Consortium, CHD Exome+ Consortium, CARDIOGRAM Exome Consortium, Deloukas, Panos, Danesh, John, Goodarzi, Mark O, Kathiresan, Sekar, Meigs, James B, Ehm, Margaret G, Wareham, Nicholas J, Waterworth, Dawn M

مصطلحات موضوعية: Receptor, Cannabinoid, CB2, Sodium-Glucose Transporter 1, Diabetes Mellitus, Type 2, Genotype, Dipeptidyl Peptidase 4, Receptor, Serotonin, 5-HT2C, Humans, Coronary Disease, Obesity, Receptors, Somatostatin, Alleles, Glucagon-Like Peptide-1 Receptor, 3. Good health

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::23453cd87fad81489808448834772462Test