التفاصيل البيبلوغرافية
| العنوان: |
Translational Regulators Maintain Totipotency in the Caenorhabditis elegans Germline |
| المؤلفون: |
Ciosk, Rafal, DePalma, Michael, Priess, James R. |
| المصدر: |
Science ; volume 311, issue 5762, page 851-853 ; ISSN 0036-8075 1095-9203 |
| بيانات النشر: |
American Association for the Advancement of Science (AAAS) |
| سنة النشر: |
2006 |
| الوصف: |
The molecular mechanisms that maintain totipotency of the germline are not well understood. Here, we show that two conserved translational regulators, MEX-3 and GLD-1, are essential for maintaining totipotency in the Caenorhabditis elegans germline. In mex-3 gld-1 mutants, germ cells transdifferentiate into various somatic cell types such as muscles or neurons. Our findings implicate RNA regulation in the maintenance of totipotency, suggest that multiple mechanisms maintain totipotency at different stages of germline development, and establish a genetically tractable model for studying the development of teratomas. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1126/science.1122491 |
| الإتاحة: |
https://doi.org/10.1126/science.1122491Test |
| رقم الانضمام: |
edsbas.E69026DB |
| قاعدة البيانات: |
BASE |
