التفاصيل البيبلوغرافية
| العنوان: |
dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway |
| المؤلفون: |
Osterloh, Jeannette M., Yang, Jing, Rooney, Timothy M., Fox, A. Nicole, Adalbert, Robert, Powell, Eric H., Sheehan, Amy E., Avery, Michelle A., Hackett, Rachel, Logan, Mary A., MacDonald, Jennifer M., Ziegenfuss, Jennifer S., Milde, Stefan, Hou, Ying-Ju, Nathan, Carl, Ding, Aihao, Brown, Robert H., Conforti, Laura, Coleman, Michael, Tessier-Lavigne, Marc, Züchner, Stephan, Freeman, Marc R. |
| المصدر: |
Science ; volume 337, issue 6093, page 481-484 ; ISSN 0036-8075 1095-9203 |
| بيانات النشر: |
American Association for the Advancement of Science (AAAS) |
| سنة النشر: |
2012 |
| الوصف: |
Sarm-Assisted Suicide Neurodegenerative disease or nerve lesions cause axons and synapses to disintegrate through a process known as Wallerian degeneration, which may involve an active “axon death program.” Osterloh et al. (p. 481 , published online 7 June; see the Perspective by Yu and Luo ) identify loss-of-function mutations in Drosophila dSarm that are capable of blocking the degeneration of severed axons for the fly life span. Deletion of mouse Sarm1 provides similar protection to severed axons for weeks after injury, which suggests that Sarm is part of an ancient axonal death signaling cascade. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1126/science.1223899 |
| الإتاحة: |
https://doi.org/10.1126/science.1223899Test |
| رقم الانضمام: |
edsbas.DF794246 |
| قاعدة البيانات: |
BASE |
