Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
| العنوان: | Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration |
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| المؤلفون: | Antonio J. Oliveira-dos-Santos, Josef M. Penninger, Junko Irie-Sasaki, Akira Suzuki, Ivona Kozieradzki, Andrew Wakeham, Takehiko Sasaki, Brad Bolon, William L. Stanford, Annick Itie, Dennis Bouchard, Nicholas Joza, Tak W. Mak, Pamela S. Ohashi, Russell G. Jones |
| المصدر: | Science. 287:1040-1046 |
| بيانات النشر: | American Association for the Advancement of Science (AAAS), 2000. |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | Thymocyte, Multidisciplinary, medicine.anatomical_structure, Kinase, P110δ, T cell, Ribosomal protein s6, medicine, Biology, Signal transduction, Protein kinase A, Protein kinase B, Cell biology |
| الوصف: | Phosphoinositide 3-kinases (PI3Ks) regulate fundamental cellular responses such as proliferation, apoptosis, cell motility, and adhesion. Viable gene-targeted mice lacking the p110 catalytic subunit of PI3Kgamma were generated. We show that PI3Kgamma controls thymocyte survival and activation of mature T cells but has no role in the development or function of B cells. PI3Kgamma-deficient neutrophils exhibited severe defects in migration and respiratory burst in response to heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPCR) agonists and chemotactic agents. PI3Kgamma links GPCR stimulation to the formation of phosphatidylinositol 3,4,5-triphosphate and the activation of protein kinase B, ribosomal protein S6 kinase, and extracellular signal-regulated kinases 1 and 2. Thus, PI3Kgamma regulates thymocyte development, T cell activation, neutrophil migration, and the oxidative burst. |
| تدمد: | 1095-9203 0036-8075 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::00515b3af3c4af1d0531a6b69bf6ba24Test https://doi.org/10.1126/science.287.5455.1040Test |
| رقم الانضمام: | edsair.doi...........00515b3af3c4af1d0531a6b69bf6ba24 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10959203 00368075 |
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