The histone demethylase KDM6B regulates temperature-dependent sex determination in a turtle species
| العنوان: | The histone demethylase KDM6B regulates temperature-dependent sex determination in a turtle species |
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| المؤلفون: | Haiyan Zhang, Blanche Capel, Chutian Ge, Cheng Cai, Jian Ye, Guoying Qian, Yingjie Zhou, Wei Sun, Ceri Weber |
| المصدر: | Science. 360:645-648 |
| بيانات النشر: | American Association for the Advancement of Science (AAAS), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0106 biological sciences, 0301 basic medicine, Jumonji Domain-Containing Histone Demethylases, Gonad, 010603 evolutionary biology, 01 natural sciences, Histones, 03 medical and health sciences, Histone H3, medicine, Animals, Epigenetics, Promoter Regions, Genetic, Ovum, Regulation of gene expression, Multidisciplinary, Temperature-dependent sex determination, biology, Temperature, Gene Expression Regulation, Developmental, DNA Methylation, Sex Determination Processes, Sex reversal, Turtles, Cell biology, Sexual dimorphism, 030104 developmental biology, medicine.anatomical_structure, Gene Knockdown Techniques, biology.protein, Demethylase, Female, Transcription Factors |
| الوصف: | Making males and back again Temperature-dependent sex determination occurs in many reptilian species. An epigenetic mechanism is presumed to be at work, but thus far it has not been identified. Ge et al. show that in the red-eared slider turtle, an epigenetic modifier, the histone demethylase KDM6B, binds to the promoter of the dominant male gene to activate male development (see the Perspective by Georges and Holleley). Knock down the expression of KDM6B, and embryos destined to be male turn into females. Science , this issue p. 645 ; see also p. 601 |
| تدمد: | 1095-9203 0036-8075 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5644d1abeef412e322bc742516d905fTest https://doi.org/10.1126/science.aap8328Test |
| رقم الانضمام: | edsair.doi.dedup.....b5644d1abeef412e322bc742516d905f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10959203 00368075 |
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