HTLV-I Tax Protein Stimulation of DNA Binding of bZIP Proteins by Enhancing Dimerization
| العنوان: | HTLV-I Tax Protein Stimulation of DNA Binding of bZIP Proteins by Enhancing Dimerization |
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| المؤلفون: | Susanne Wagner, Michael R. Green |
| المصدر: | Science. 262:395-399 |
| بيانات النشر: | American Association for the Advancement of Science (AAAS), 1993. |
| سنة النشر: | 1993 |
| مصطلحات موضوعية: | HMG-box, Polymers, Recombinant Fusion Proteins, viruses, Molecular Sequence Data, genetic processes, Activating transcription factor, Biology, environment and public health, Cell Line, Binding site, Cyclic AMP Response Element-Binding Protein, Plant Proteins, Activating Transcription Factor 1, Leucine Zippers, Binding Sites, Multidisciplinary, Activating Transcription Factor 2, Base Sequence, bZIP domain, DNA, Gene Products, tax, DNA-binding domain, Cell Transformation, Viral, G-Box Binding Factors, Molecular biology, Cell biology, DNA-Binding Proteins, DNA binding site, Basic-Leucine Zipper Transcription Factors, Oligodeoxyribonucleotides, Transcription Factors, Binding domain |
| الوصف: | The Tax protein of human T cell leukemia virus type-1 (HTLV-I) transcriptionally activates the HTLV-I promoter. This activation requires binding sites for activating transcription factor (ATF) proteins, a family of cellular proteins that contain basic region-leucine zipper (bZIP) DNA binding domains. Data are presented showing that Tax increases the in vitro DNA binding activity of multiple ATF proteins. Tax also stimulated DNA binding by other bZIP proteins, but did not affect DNA binding proteins that lack a bZIP domain. The increase in DNA binding occurred because Tax promotes dimerization of the bZIP domain in the absence of DNA, and the elevated concentration of the bZIP homodimer then facilitates the DNA binding reaction. These results help explain how Tax activates viral transcription and transforms cells. |
| تدمد: | 1095-9203 0036-8075 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18fdc132875af5b2e8e5586340d481c3Test https://doi.org/10.1126/science.8211160Test |
| رقم الانضمام: | edsair.doi.dedup.....18fdc132875af5b2e8e5586340d481c3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10959203 00368075 |
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