التفاصيل البيبلوغرافية
| العنوان: |
3D genomics across the tree of life reveals condensin II as a determinant of architecture type |
| المؤلفون: |
Hoencamp, Claire, Dudchenko, Olga, Elbatsh, Ahmed M. O., Schaik, Tom van, Sedeño Cacciatore, Ángela, Contessoto, Vinícius G., Van Heesbeen, Roy G. H. P, Van den Broek, Bram, Mhaskar, Aditya N., Teunissen, Hans, Glenn St Hilaire, Brian, Weisz, David, Omer, Arina D., Pham, Melanie, Colaric, Zane, Yang, Zhenzhen, Rao, Suhas S. P., Mitra, Namita, Lui, Christopher, Yao, Weijie, Khan, Ruqayya, Moroz, Leonid L., Kohn, Andrea, Leger, Judy St., Mena, Alexandria, Holcroft, Karen, Gambetta, Maria Cristina, Lim, Fabian, Farley, Emma, Stein, Nils, Haddad, Alexander, Chauss, Daniel, Sena Mutlu, Ayse, Wang, Meng C., Young, Neil D., Hildebrandt, Evin, Chen, Hans H., Knight, Christopher J., Burnham, Theresa L. U., Hovel, Kevin A., Beel, Andrew J., Mattei, Pierre-Jean, Kornberg, Roger D., Warren, Wesley C., Cary, Gregory, Gómez-Skarmeta, José Luis, Hinman, Verónica, Lindblad-Toh, Kerstin, Palma, Federica Di, Maeshima, Kazuhiro, Multani, Asha S., Pathak, Sen, Nel-Themaat, Liesl, Behringer, Richard R., Kaur, Parwinder, Medem, René H., Steensel, Bas van, Wit, Elzo de, Onuchic, José N., Pierro, Michele Di, Lieberman Aiden, Erez, Rowland, Benjamin D. |
| المساهمون: |
European Commission, Dutch Research Council, Dutch Cancer Society, Welch Foundation, Sao Paulo Research Foundation, Cancer Research UK, University of Western Australia, National Institutes of Health (US), Illumina, European Research Council, Ministerio de Economía y Competitividad (España) |
| بيانات النشر: |
American Association for the Advancement of Science |
| سنة النشر: |
2021 |
| مصطلحات موضوعية: |
archi, envir |
| الوصف: |
We investigated genome folding across the eukaryotic tree of life. We find two types of three-dimensional(3D) genome architectures at the chromosome scale. Each type appears and disappears repeatedlyduring eukaryotic evolution. The type of genome architecture that an organism exhibits correlates with theabsence of condensin II subunits. Moreover, condensin II depletion converts the architecture of thehuman genome to a state resembling that seen in organisms such as fungi or mosquitoes. In this state,centromeres cluster together at nucleoli, and heterochromatin domains merge. We propose a physicalmodel in which lengthwise compaction of chromosomes by condensin II during mitosis determineschromosome-scale genome architecture, with effects that are retained during the subsequent interphase.This mechanism likely has been conserved since the last common ancestor of all eukaryotes. ; C.H. is supported by the Boehringer Ingelheim Fonds; C.H., Á.S.C., and B.D.R. are supported by an ERC CoG (772471, “CohesinLooping”); A.M.O.E. and B.D.R. are supported by the Dutch Research Council (NWO-Echo); and J.A.R. and R.H.M. are supported by the Dutch Cancer Society (KWF). T.v.S. and B.v.S. are supported by NIH Common Fund “4D Nucleome” Program grant U54DK107965. H.T. and E.d.W. are supported by an ERC StG (637597, “HAP-PHEN”). J.A.R., T.v.S., H.T., R.H.M., B.v.S., and E.d.W. are part of the Oncode Institute, which is partly financed by the Dutch Cancer Society. Work at the Center for Theoretical Biological Physics is sponsored by the NSF (grants PHY-2019745 and CHE-1614101) and by the Welch Foundation (grant C-1792). V.G.C. is funded by FAPESP (São Paulo State Research Foundation and Higher Education Personnel) grants 2016/13998-8 and 2017/09662-7. J.N.O. is a CPRIT Scholar in Cancer Research. E.L.A. was supported by an NSF Physics Frontiers Center Award (PHY-2019745), the Welch Foundation (Q-1866), a USDA Agriculture and Food Research Initiative grant (2017-05741), the Behavioral Plasticity Research Institute (NSF DBI-2021795), . |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
http://hdl.handle.net/10261/260058Test |
| الإتاحة: |
http://hdl.handle.net/10261/260058Test |
| حقوق: |
undefined |
| رقم الانضمام: |
edsbas.BA6037A4 |
| قاعدة البيانات: |
BASE |
