دورية أكاديمية
The impact of sex on gene expression across human tissues
| العنوان: | The impact of sex on gene expression across human tissues |
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| المؤلفون: | Oliva, Meritxell, Muñoz-Aguirre, Manuel, Kim-Hellmuth, Sarah, Wucher, Valentin, Gewirtz, Ariel DH, Cotter, Daniel J., Parsana, Princy, Kasela, Silva, Balliu, Brunilda, Viñuela, Ana, Castel, Stephane E., Mohammadi, Pejman, Aguet, François, Zou, Yuxin, Khramtsova, Ekaterina A., Skol, Andrew D., Garrido-Martín, Diego, Reverter Comes, Ferran, Brown, Andrew, Evans, Patrick, Gamazon, Eric R., Payne, Anthony, Bonazzola, Rodrigo, Barbeira, Alvaro N., Hamel, Andrew R., Martinez-Perez, Angel, Soria, José Manuel, Consortium, GTEx, Pierce, Brandon L, Stephens, Matthew, Eskin, Eleazar, Dermitzakis, Emmanouil T., Segrè, Ayellet V, Kyung Im, Hae, Engelhardt, Barbara E., Ardlie, Kristin G ., Montgomery, Stephen B., Battle, Alexis J., Lappalainen, Tuuli, Guigó, Roderic |
| المصدر: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
| بيانات النشر: | American Association for the Advancement of Science |
| سنة النشر: | 2020 |
| المجموعة: | Dipòsit Digital de la Universitat de Barcelona |
| مصطلحات موضوعية: | Cromosomes sexuals, Expressió gènica, Genoma humà, Sex chromosomes, Gene expression, Human genome |
| الوصف: | Many complex human phenotypes exhibit sex-differentiated characteristics. However, the molecular mechanisms underlying these differences remain largely unknown. We generated a catalog of sex differences in gene expression and in the genetic regulation of gene expression across 44 human tissue sources surveyed by the Genotype-Tissue Expression project (GTEx, v8 release). We demonstrate that sex influences gene expression levels and cellular composition of tissue samples across the human body. A total of 37% of all genes exhibit sex-biased expression in at least one tissue. We identify cis expression quantitative trait loci (eQTLs) with sex-differentiated effects and characterize their cellular origin. By integrating sex-biased eQTLs with genome-wide association study data, we identify 58 gene-trait associations that are driven by genetic regulation of gene expression in a single sex. These findings provide an extensive characterization of sex differences in the human transcriptome and its genetic regulation. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 14 p.; application/pdf |
| اللغة: | English |
| تدمد: | 0036-8075 |
| العلاقة: | Versió postprint del document publicat a: https://doi.org/10.1126/science.aba3066Test; Science, 2020, vol. 369, num. 6509; https://doi.org/10.1126/science.aba3066Test; http://hdl.handle.net/2445/197187Test; 705027 |
| الإتاحة: | https://doi.org/10.1126/science.aba3066Test http://hdl.handle.net/2445/197187Test |
| حقوق: | (c) Oliva, Meritxell et al., 2020 ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.39EBFB93 |
| قاعدة البيانات: | BASE |
| تدمد: | 00368075 |
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