التفاصيل البيبلوغرافية
| العنوان: |
Neuronal activity induces glucosylceramide that is secreted via exosomes for lysosomal degradation in glia. |
| المؤلفون: |
Liping Wang1,2, Guang Lin2,3, Zhongyuan Zuo2,3, Yarong Li2,4, Seul Kee Byeon5, Pandey, Akhilesh5,6,7, Bellen, Hugo J.1,2,3,4 hbellen@bcm.edu |
| المصدر: |
Science Advances. 7/15/2022, Vol. 8 Issue 28, p1-20. 20p. |
| مصطلحات موضوعية: |
*LYSOSOMES, *TRP channels, *ATP-binding cassette transporters, *INSULIN-like growth factor-binding proteins, *EXOSOMES |
| مستخلص: |
The article discusses how Gba1b is expressed in glia but not in neurons by generating a null allele of the Drosophila ortholog Gba1b by inserting the Gal4 using CRISPR-Cas9. Topics discussed include studies in flies fish, and mice showing that loss of GBA1 orthologs leads to GlcCer accumulation, lysosomal dysfunction, ubiquitinated protein aggregation, and loss of Gba1b leads to abnormal glia morphology and progressive neurodegeneration. |
| قاعدة البيانات: |
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