دورية أكاديمية
Cooperativity Between T Cell Receptor Complexes Revealed by Conformational Mutants of CD3ɛ
| العنوان: | Cooperativity Between T Cell Receptor Complexes Revealed by Conformational Mutants of CD3ɛ |
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| المؤلفون: | Martínez-Martín, Nuria, Risueño, Ruth M., Morreale, Antonio, Zaldívar Notario, Irene, Fernández-Arenas, Elena, Herranz, Fernando, Ortiz, Ángel R., Alarcón, Balbino |
| بيانات النشر: | American Association for the Advancement of Science |
| سنة النشر: | 2009 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| الوصف: | The CD3ɛ subunit of the T cell receptor (TCR) complex undergoes a conformational change upon ligand binding that is thought to be important for the activation of T cells. To study this process, we built a molecular dynamics model of the transmission of the conformational change within the ectodomains of CD3. The model showed that the CD3 dimers underwent a stiffening effect that was funneled to the base of the CD3ɛ subunit. Mutation of two relevant amino acid residues blocked transmission of the conformational change and the differentiation and activation of T cells. Furthermore, this inhibition occurred even in the presence of excess endogenous CD3ɛ subunits. These results emphasize the importance of the conformational change in CD3ɛ for the activation of T cells and suggest the existence of unforeseen cooperativity between TCR complexes. ; Peer reviewed |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1945-0877 1937-9145 |
| العلاقة: | http://dx.doi.org/10.1126/scisignal.2000402Test; Sí; Science Signaling 2(83): ra43 (2009); http://hdl.handle.net/10261/345380Test |
| DOI: | 10.1126/scisignal.2000402 |
| الإتاحة: | https://doi.org/10.1126/scisignal.2000402Test http://hdl.handle.net/10261/345380Test |
| حقوق: | none |
| رقم الانضمام: | edsbas.5D2DACD3 |
| قاعدة البيانات: | BASE |
| تدمد: | 19450877 19379145 |
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| DOI: | 10.1126/scisignal.2000402 |