التفاصيل البيبلوغرافية
| العنوان: |
Tight Coordination of Protein Translation and HSF1 Activation Supports the Anabolic Malignant State. |
| المؤلفون: |
Santagata, Sandro, Mendillo, Marc L., Yun-chi Tang, Subramanian, Aravind, Perley, Casey C., Roche, Stéphane P., Bang Wong, Narayan, Rajiv, Kwon, Hyoungtae, Koeva, Martina, Amon, Angelika, Golub, Todd R., Porco Jr., John A., Whitesell, Luke whitesell@wi.mit.edu, Lindquist, Susan lindquist_admin@wi.mit.edu |
| المصدر: |
Science. 7/19/2013, Vol. 341 Issue 6143, p250-250. 1p. |
| مصطلحات موضوعية: |
*RIBOSOMES, *TRANSCRIPTION factors, *MESSENGER RNA, *CELLULAR control mechanisms, *TUMOR growth, *THIOREDOXIN-interacting protein |
| مستخلص: |
The article discusses research in ribosome biogenesis, with a focus on the ribosome's translational activity and activation of HSF1, the heat-shock transcription factor. Topics include tumor growth and malignant states associated with anabolic demands, ribosome regulation and cancer incidence, and eukaryotic initiation factors (elFs). Additional information is presented on thioredoxin-interacting protein (TXNIP) messenger RNA (mRNA), glucose uptake and translational flux, and acute myeloid leukemia cells. |
| قاعدة البيانات: |
Academic Search Index |
