GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment

التفاصيل البيبلوغرافية
العنوان:	GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
المؤلفون:	Rietveld, C. A., Medland, S. E., Derringer, J., Yang, J., Esko, T., Martin, N. W., Westra, H.-J., Shakhbazov, K., Abdellaoui, A., Agrawal, A., Albrecht, E., Alizadeh, B. Z., Amin, N., Barnard, J., Baumeister, S. E., Benke, K. S., Bielak, L. F., Boatman, J. A., Boyle, P. A., Davies, G., de Leeuw, C., Eklund, N., Evans, D. S., Ferhmann, R., Fischer, K., Gieger, C., Gjessing, H. K., Hagg, S., Harris, J. R., Hayward, C., Holzapfel, C., Ibrahim-Verbaas, C. A., Ingelsson, E., Jacobsson, B., Joshi, P. K., Jugessur, A., Kaakinen, M., Kanoni, S., Karjalainen, J., Kolcic, I., Kristiansson, K., Kutalik, Z., Lahti, J., Lee, S. H., Lin, P., Lind, P. A., Liu, Y., Lohman, K., Loitfelder, M., McMahon, G., Vidal, P. M., Meirelles, O., Milani, L., Myhre, R., Nuotio, M.-L., Oldmeadow, C. J., Petrovic, K. E., Peyrot, W. J., Polasek, O., Quaye, L., Reinmaa, E., Rice, J. P., Rizzi, T. S., Schmidt, H., Schmidt, R., Smith, A. V., Smith, J. A., Tanaka, T., Terracciano, A., Van der Loos, M.J.H.M, Vitart, V., Volzke, H., Wellmann, J., Yu, L., Zhao, W., Allik, J., Attia, J. R., Bandinelli, S., Bastardot, F., Beauchamp, J., Bennett, D. A., Berger, K., Bierut, L. J., Boomsma, D. I., Bultmann, U., Campbell, H., Chabris, C. F., Cherkas, L., Chung, M. K., Cucca, F., de Andrade, M., De Jager, P. L., De Neve, Jan-Emmanuel, Deary, I. J., Dedoussis, G. V., Deloukas, P., Dimitriou, M., Eiriksdottir, G., Elderson, M. F., Eriksson, J. G., Evans, D. M., Faul, J. D., Ferrucci, L., Garcia, M. E., Gronberg, H., Guthnason, V., Hall, P., Harris, J. M., Harris, T. B., Hastie, N. D., Heath, A. C., Hernandez, D. G., Hoffmann, W., Hofman, A., Holle, R., Holliday, E. G., Hottenga, J.-J., Iacono, W. G., Illig, T., Jarvelin, M.-R., Kahonen, M., Kaprio, J., Kirkpatrick, R. M., Kowgier, M., Latvala, A., Launer, L. J., Lawlor, D. A., Lehtimaki, T., Li, J., Lichtenstein, P., Lichtner, P., Liewald, D. C., Madden, P. A., Magnusson, P. K. E., Makinen, T. E., Masala, M., McGue, M., Metspalu, A., Mielck, A., Miller, M. B., Montgomery, G. W., Mukherjee, S., Nyholt, D. R., Oostra, B. A., Palmer, L. J., Palotie, A., Penninx, B. W. J. H., Perola, M., Peyser, P. A., Preisig, M., Raikkonen, K., Raitakari, O. T., Realo, A., Ring, S. M., Ripatti, S., Rivadeneira, F., Rudan, I., Rustichini, A., Salomaa, V., Sarin, A.-P., Schlessinger, D., Scott, R. J., Snieder, H., St Pourcain, B., Starr, J. M., Sul, J. H., Surakka, I., Svento, R., Teumer, A., Tiemeier, H., van Rooij, F. J. A., Van Wagoner, D. R., Vartiainen, E., Viikari, J., Vollenweider, P., Vonk, J. M., Waeber, G., Weir, D. R., Wichmann, H.- E., Widen, E., Willemsen, G., Wilson, J. F., Wright, A. F., Conley, D., Davey-Smith, G., Franke, L., Groenen, P. J. F., Johannesson, M., Kardia, S. L. R., Krueger, R. F., Laibson, D., Martin, N. G., Meyer, M. N., Posthuma, D., Thurik, A. R., Timpson, N. J., Uitterlinden, A. G., van Duijn, C. M., Visscher, P. M., Benjamin, D. J., Cesarini, D., Koellinger, P. D.
بيانات النشر:	American Association for the Advancement of Science
سنة النشر:	2013
المجموعة:	The London School of Economics and Political Science: LSE Research Online
مصطلحات موضوعية:	L Education (General), LB Theory and practice of education
الوصف:	A genome-wide association study (GWAS) of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent single-nucleotide polymorphisms (SNPs) are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (coefficient of determination R2≈ 0.02%), approximately 1 month of schooling per allele. A linear polygenic score from all measured SNPs accounts for ≈2% of the variance in both educational attainment and cognitive function. Genes in the region of the loci have previously been associated with health, cognitive, and central nervous system phenotypes, and bioinformatics analyses suggest the involvement of the anterior caudate nucleus. These findings provide promising candidate SNPs for follow-up work, and our effect size estimates can anchor power analyses in social-science genetics.
نوع الوثيقة:	article in journal/newspaper
اللغة:	English
العلاقة:	Rietveld, C. A., Medland, S. E., Derringer, J., Yang, J., Esko, T., Martin, N. W., Westra, H.-J., Shakhbazov, K., Abdellaoui, A., Agrawal, A., Albrecht, E., Alizadeh, B. Z., Amin, N., Barnard, J., Baumeister, S. E., Benke, K. S., Bielak, L. F., Boatman, J. A., Boyle, P. A., Davies, G., de Leeuw, C., Eklund, N., Evans, D. S., Ferhmann, R., Fischer, K., Gieger, C., Gjessing, H. K., Hagg, S., Harris, J. R., Hayward, C., Holzapfel, C., Ibrahim-Verbaas, C. A., Ingelsson, E., Jacobsson, B., Joshi, P. K., Jugessur, A., Kaakinen, M., Kanoni, S., Karjalainen, J., Kolcic, I., Kristiansson, K., Kutalik, Z., Lahti, J., Lee, S. H., Lin, P., Lind, P. A., Liu, Y., Lohman, K., Loitfelder, M., McMahon, G., Vidal, P. M., Meirelles, O., Milani, L., Myhre, R., Nuotio, M.-L., Oldmeadow, C. J., Petrovic, K. E., Peyrot, W. J., Polasek, O., Quaye, L., Reinmaa, E., Rice, J. P., Rizzi, T. S., Schmidt, H., Schmidt, R., Smith, A. V., Smith, J. A., Tanaka, T., Terracciano, A., Van der Loos, M.J.H.M, Vitart, V., Volzke, H., Wellmann, J., Yu, L., Zhao, W., Allik, J., Attia, J. R., Bandinelli, S., Bastardot, F., Beauchamp, J., Bennett, D. A., Berger, K., Bierut, L. J., Boomsma, D. I., Bultmann, U., Campbell, H., Chabris, C. F., Cherkas, L., Chung, M. K., Cucca, F., de Andrade, M., De Jager, P. L., De Neve, Jan-Emmanuel, Deary, I. J., Dedoussis, G. V., Deloukas, P., Dimitriou, M., Eiriksdottir, G., Elderson, M. F., Eriksson, J. G., Evans, D. M., Faul, J. D., Ferrucci, L., Garcia, M. E., Gronberg, H., Guthnason, V., Hall, P., Harris, J. M., Harris, T. B., Hastie, N. D., Heath, A. C., Hernandez, D. G., Hoffmann, W., Hofman, A., Holle, R., Holliday, E. G., Hottenga, J.-J., Iacono, W. G., Illig, T., Jarvelin, M.-R., Kahonen, M., Kaprio, J., Kirkpatrick, R. M., Kowgier, M., Latvala, A., Launer, L. J., Lawlor, D. A., Lehtimaki, T., Li, J., Lichtenstein, P., Lichtner, P., Liewald, D. C., Madden, P. A., Magnusson, P. K. E., Makinen, T. E., Masala, M., McGue, M., Metspalu, A., Mielck, A., Miller, M. B., Montgomery, G. W., Mukherjee, S., Nyholt, D. R., Oostra, B. A., Palmer, L. J., Palotie, A., Penninx, B. W. J. H., Perola, M., Peyser, P. A., Preisig, M., Raikkonen, K., Raitakari, O. T., Realo, A., Ring, S. M., Ripatti, S., Rivadeneira, F., Rudan, I., Rustichini, A., Salomaa, V., Sarin, A.-P., Schlessinger, D., Scott, R. J., Snieder, H., St Pourcain, B., Starr, J. M., Sul, J. H., Surakka, I., Svento, R., Teumer, A., Tiemeier, H., van Rooij, F. J. A., Van Wagoner, D. R., Vartiainen, E., Viikari, J., Vollenweider, P., Vonk, J. M., Waeber, G., Weir, D. R., Wichmann, H.- E., Widen, E., Willemsen, G., Wilson, J. F., Wright, A. F., Conley, D., Davey-Smith, G., Franke, L., Groenen, P. J. F., Hofman, A., Johannesson, M., Kardia, S. L. R., Krueger, R. F., Laibson, D., Martin, N. G., Meyer, M. N., Posthuma, D., Thurik, A. R., Timpson, N. J., Uitterlinden, A. G., van Duijn, C. M., Visscher, P. M., Benjamin, D. J., Cesarini, D. and Koellinger, P. D. (2013) GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment. Science, 340 (6139). pp. 1467-1471. ISSN 0036-8075
الإتاحة:	http://eprints.lse.ac.uk/51056Test/ http://www.sciencemag.orgTest/
رقم الانضمام:	edsbas.D6F3A8B
قاعدة البيانات:	BASE

View record in BASE

الوصف
الوصف غير متاح.