التفاصيل البيبلوغرافية
| العنوان: |
CTLA-4 Control over Foxp3+ Regulatory T Cell Function. |
| المؤلفون: |
Wing, Kajsa1, Onishi, Yasushi1,2, Prieto-Martin, Paz1, Yamaguchi, Tomoyuki1, Miyara, Makoto1, Fehervari, Zoltan, Nomura, Takashi1, Sakaguchi, Shimon1,3,4 shimon@frontier.kyoto-u.ac.jp |
| المصدر: |
Science. 10/10/2008, Vol. 322 Issue 5899, p271-275. 5p. |
| مصطلحات موضوعية: |
*IMMUNOLOGICAL tolerance, *CELL-mediated cytotoxicity, *T cells, *HOMEOSTASIS, *LYMPHOID tissue, *DENDRITIC cells |
| مستخلص: |
Naturally occurring Foxp3+CD4+ regulatory T cells (Tregs) are essential for maintaining immunological self-tolerance and immune homeostasis. Here, we show that a specific deficiency of cytotoxic T lymphocyte antigen 4 (CTLA-4) in Tregs results in spontaneous development of systemic lymphoproliferation, fatal T cell-mediated autoimmune disease, and hyperproduction of immunoglobulin E in mice, and it also produces potent tumor immunity. Treg-specific CTLA-4 deficiency impairs in vivo and in vitro suppressive function of Tregs—in particular, Treg-mediated down-regulation of CD80 and CD86 expression on dendritic cells. Thus, natural Tregs may critically require CTLA-4 to suppress immune responses by affecting the potency of antigen-presenting cells to activate other T cells. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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