التفاصيل البيبلوغرافية
| العنوان: |
Ubiquitin-Binding Protein RAP80 Mediates BRCA1-Dependent DNA Damage Response. |
| المؤلفون: |
Hongtae Kim1, Junjie Chen1 Junjie.chen@yale.edu, Xiaochun Yu2 xiayu@med.umich.edu |
| المصدر: |
Science. 5/25/2007, Vol. 316 Issue 5828, p1202-1205. 4p. 3 Diagrams, 1 Graph. |
| مصطلحات موضوعية: |
*MUTAGENESIS, *CANCER genes, *BIOLOGICAL transport, *CARRIER proteins, *RECEPTOR antibodies, *UBIQUITIN, *DNA damage, *CANCER genetics, *BIOCHEMICAL genetics, *GENETIC mutation |
| مستخلص: |
Mutations in the breast cancer susceptibility gene 1 (BRCA1) are associated with an increased risk of breast and ovarian cancers. BRCA1 participates in the cellular DNA damage response. We report the identification of receptor-associated protein 80 (RAP80) as a BRCA1-interacting protein in humans. RAP80 contains a tandem ubiquitin-interacting motif domain, which is required for its binding with ubiquitin in vitro and its damage-induced foci formation in vivo. Moreover, RAP80 specifically recruits BRCA1 to DNA damage sites and functions with BRCA1 in G2/M checkpoint control. Together, these results suggest the existence of a ubiquitination-dependent signaling pathway involved in the DNA damage response. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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