التفاصيل البيبلوغرافية
| العنوان: |
The telomerase reverse transcriptase elongates reversed replication forks at telomeric repeats. |
| المؤلفون: |
Huda, Armela1, Hiroshi Arakawa1, Mazzucco, Giulia1, Galli, Martina1, Petrocelli, Valentina2, Casola, Stefano1, Lu Chen3,4, Doksani, Ylli1 ylli.doksani@ifom.eu |
| المصدر: |
Science Advances. 3/24/2023, Vol. 9 Issue 12, p1-11. 11p. |
| مصطلحات موضوعية: |
*TELOMERASE reverse transcriptase, *FORKS, *TELOMERASE, *DNA replication, *MOLECULAR size, *SV40 (Virus) |
| مستخلص: |
The article discusses a research in the journal "Science Advance" that have discovered that telomeres, which are the repetitive DNA sequences located at the ends of chromosomes, are replication hotspots. The study found that telomerase, the enzyme responsible for adding telomeric repeats to chromosome ends, elongates these reversed forks. This discovery could provide insight into how telomere replication defects contribute to the aging process and disease. |
| قاعدة البيانات: |
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