التفاصيل البيبلوغرافية
| العنوان: |
A MYCN-independent mechanism mediating secretome reprogramming and metastasis in MYCN-amplified neuroblastoma. |
| المؤلفون: |
Hai-Feng Zhang1,2, Delaidelli, Alberto1,2, Javed, Sumreen3, Turgu, Busra1,2, Morrison, Taylor2, Hughes, Christopher S.1,2, Xiaqiu Yang2, Pachva, Manideep1,2, Lizardo, Michael M.1,2, Singh, Gurdeep2, Hoffmann, Jennifer4, Yue Zhou Huang2, Patel, Khushbu4,5, Shraim, Rawan4,6, Kung, Sonia H. Y.7, Morin, Gregg B.8,9, Aparicio, Samuel1,2, Martinez, Daniel4,5, Maris, John M.4,5, Bosse, Kristopher R.4,5 |
| المصدر: |
Science Advances. 8/25/2023, Vol. 9 Issue 34, p1-17. 17p. |
| مصطلحات موضوعية: |
*ANDROGEN receptors, *GENETIC regulation, *MACROPHAGE migration inhibitory factor |
| مستخلص: |
The article focuses on understanding the role of the GREB1 gene in MYCN-amplified neuroblastoma (NB), a high-risk pediatric cancer. It is reported that GREB1 is found to promote cell survival independently of MYCN and is highly expressed in MYCN-amplified NB. It also identifies MYO1B as a key gene in NB, influencing invasion and metastasis. |
| قاعدة البيانات: |
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