التفاصيل البيبلوغرافية
| العنوان: |
Circadian Rhythm of Redox State Regulates Excitability in Suprachiasmatic Nucleus Neurons. |
| المؤلفون: |
Wang, Tongfei A.1, Yu, Yanxun V.2,3, Govindaiah, Gubbi1,4, Xiaoying Ye4,5,6, Artinian, Liana1,7, Coleman, Todd P.8, Sweedler, Jonathan V.1,2,4,5, Cox, Charles L.1,2,5, Gillettee, Martha U.4,5,9 mgillett@illinois.edu |
| المصدر: |
Science. 8/17/2012, Vol. 337 Issue 6096, p839-842. 4p. |
| مصطلحات موضوعية: |
*CIRCADIAN rhythms, *SUPRACHIASMATIC nucleus, *OXIDATION-reduction reaction, *NEURAL physiology, *MAMMAL genetics, *PHYSIOLOGICAL control systems |
| مستخلص: |
Daily rhythms of mammalian physiology, metabolism, and behavior parallel the day-night cycle. They are orchestrated by a central circadian dock in the brain, the suprachiasmatic nucleus (SCN). Transcription of clock genes is sensitive to metabolic changes in reduction and oxidation (redox); however, circadian cycles in protein oxidation have been reported in anudeate cells, where no transcription occurs. We investigated whether the SCN also expresses redox cycles and how such metabolic oscillations might affect neuronal physiology. We detected self-sustained circadian rhythms of SCN redox state that required the molecular clockwork. The redox oscillation could determine the excitability of SCN neurons through nontranscriptional modulation of multiple potassium (K+) channels. Thus, dynamic regulation of SCN excitability appears to be closely tied to metabolism that engages the clockwork machinery. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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