التفاصيل البيبلوغرافية
| العنوان: |
Aerosol Delivery and Humidification With the Boussignac Continuous Positive Airway Pressure Device. |
| المؤلفون: |
Thille, Arnaud W., Bertholon, Jean-Franç.ois, Becquemin, Marie-Hélène, Roy, Monique, Lyazidi, Aissam, Lellouche, François, Pertusini, Esther, Boussignac, Georges, Maître, Bernard, Brochard, Laurent |
| المصدر: |
Respiratory Care; Oct2011, Vol. 56 Issue 10, p1526-1532, 7p, 2 Color Photographs, 1 Chart, 3 Graphs |
| مصطلحات موضوعية: |
OBSTRUCTIVE lung disease treatment, RESPIRATORY insufficiency treatment, CONTINUOUS positive airway pressure, ACTIVE oxygen in the body, AEROSOL therapy, ANALYSIS of variance, NONPARAMETRIC statistics, OXYGEN therapy, RESEARCH funding, RESPIRATION, RESPIRATORY muscles, RESPIRATORY therapy equipment, STATISTICS, PILOT projects, DATA analysis, CONTINUING education units, TERBUTALINE, EQUIPMENT & supplies |
| مصطلحات جغرافية: |
FRANCE |
| مستخلص: |
BACKGROUND: A simple method for effective bronchodilator aerosol delivery while administering continuing continuous positive airway pressure (CPAP) would be useful in patients with severe bronchial obstruction. OBJECTIVE: To assess the effectiveness of bronchodilator aerosol delivery during CPAP generated by the Boussignac CPAP system and its optimal humidification system. METHODS: First we assessed the relationship between flow and pressure generated in the mask with the Boussignac CPAP system. Next we measured the inspired-gas humidity during CPAP, with several humidification strategies, in 9 healthy volunteers. We then measured the bronchodilator aerosol particle size during CPAP, with and without heat-and-moisture exchanger, in a bench study. Finally, in 7 patients with acute respiratory failure and airway obstruction, we measured work of breathing and gas exchange after a β-2-agonist bronchodilator aerosol (terbutaline) delivered during CPAP or via standard nebulization. RESULTS: Optimal humidity was obtained only with the heat-and-moisture exchanger or heated humidifier. The heat-and-moisture exchanger had no influence on bronchodilator aerosol particle size. Work of breathing decreased similarly after bronchodilator via either standard nebulization or CPAP, but PaO2 increased significantly only after CPAP aerosol delivery. CONCLUSIONS: CPAP bronchodilator delivery decreases the work of breathing as effectively as does standard nebulization, but produces a greater oxygenation improvement in patients with airway obstruction. To optimize airway humidification, a heat-and-moisture exchanger could be used with the Boussignac CPAP system, without modifying aerosol delivery. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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