An Assessment of the Shared Allelic Architecture between Type II Diabetes and Prostate Cancer
| العنوان: | An Assessment of the Shared Allelic Architecture between Type II Diabetes and Prostate Cancer |
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| المؤلفون: | Oriana Hoi Yun Yu, Rosalind A. Eeles, William D. Foulkes, Zari Dastani, J. Brent Richards, Richard M. Martin |
| المصدر: | Cancer Epidemiology, Biomarkers & Prevention. 22:1473-1475 |
| بيانات النشر: | American Association for Cancer Research (AACR), 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, Oncology, medicine.medical_specialty, Genotype, Epidemiology, Genome-wide association study, Biology, Polymorphism, Single Nucleotide, Article, Prostate cancer, Risk Factors, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, Allele, Alleles, Glycemic, Framingham Risk Score, Case-control study, Prostatic Neoplasms, Cancer, medicine.disease, Endocrinology, Diabetes Mellitus, Type 2, Case-Control Studies, Female, Genome-Wide Association Study |
| الوصف: | Background: To determine whether the alleles that influence type II diabetes risk and glycemic traits also influence prostate cancer risk. Methods: We used a multiple single-nucleotide polymorphisms (SNP) genotypic risk score to assess the average effect of alleles that increase type II diabetes risk or worsen glycemic traits on risk of prostate cancer in 19,662 prostate cancer cases and 19,715 controls from the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium and 5,504 prostate cancer cases and 5,834 controls from the Cancer Research UK (CRUK) prostate cancer study. Results: Calculating the average additive effect of type II diabetes or glycemic trait risk alleles on prostate cancer risk using a logistic model revealed no evidence of a shared allelic architecture between type II diabetes, or worsened glycemic status, with prostate cancer risk [OR for type II diabetes alleles: 1.00 (P = 0.58), fasting glycemia alleles: 1.00 (P = 0.67), HbA1c alleles: 1.00 (P = 0.93), 2-hour OGTT alleles: 1.01 (P = 0.14), and HOMA-B alleles: 0.99 (P = 0.57)]. Conclusions: Using genetic data from large consortia, we found no evidence for a shared genetic etiology of type II diabetes or glycemic risk with prostate cancer. Impact: Our results showed that alleles influencing type II diabetes and related glycemic traits were not found to be associated with the risk of prostate cancer. Cancer Epidemiol Biomarkers Prev; 22(8); 1473–5. ©2013 AACR. |
| تدمد: | 1538-7755 1055-9965 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10733f58d7185656c37e911f8241a08bTest https://doi.org/10.1158/1055-9965.epi-13-0476Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....10733f58d7185656c37e911f8241a08b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15387755 10559965 |
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