-
1
المؤلفون: Sapna Nagar, Raymon H. Grogan, Paul J. Chang, Peter Angelos, Briseis Aschebrook-Kilfoy, Edwin L. Kaplan, Michael G. White, Abhineet Uppal
المصدر: Cancer Epidemiology, Biomarkers & Prevention. 24:1327-1331
مصطلحات موضوعية: Adult, Male, Thyroid nodules, medicine.medical_specialty, Epidemiology, Biopsy, Fine-Needle, Article, Tertiary Care Centers, Biopsy, Prevalence, medicine, Humans, Thyroid Neoplasms, Thyroid Nodule, Thyroid cancer, Aged, Retrospective Studies, Ultrasonography, Chicago, Incidental Findings, medicine.diagnostic_test, business.industry, Thyroid, Nodule (medicine), Magnetic resonance imaging, Retrospective cohort study, Middle Aged, medicine.disease, Magnetic Resonance Imaging, medicine.anatomical_structure, Oncology, Positron emission tomography, Positron-Emission Tomography, Female, Radiology, medicine.symptom, Tomography, X-Ray Computed, business, Nuclear medicine
الوصف: Purpose: Thyroid nodules incidentally identified on imaging are thought to contribute to the increasing incidence of thyroid cancer. We aim to determine the true rate of incidental thyroid nodule reporting, malignancy rates of these nodules, and to compare these findings with rates of detection by dedicated radiology review. Methods: A cross-sectional analysis was done to determine the prevalence of thyroid nodules in radiologist reports by analyzing all reports for CT, PET, and MRI scans of the head, neck, and chest as well as neck ultrasounds performed at a tertiary care center from 2007 to 2012. Retrospective chart review was performed on patients with a reported thyroid nodule to determine clinical outcomes of these nodules. Radiology reports were compared with dedicated radiology review of 500 randomly selected CT scans from the study group to determine the difference between clinical reporting and actual prevalence of thyroid nodules. Results: 97,908 imaging studies met inclusion criteria, and 387 (0.4%) thyroid incidentalomas were identified on radiology report. One hundred and sixty three (42.1%) of these nodules were worked up with fine-needle aspiration, diagnosing 27 thyroid cancers (0.03% of all studies, 7.0% of reported incidentalomas). The prevalence of incidentalomas clinically reported was 142/100,000 CT scans, 638/100,000 MRIs, 358/100,000 PET scans, and 6,594/100,000 ultrasounds. In contrast, review of CT scans screening for thyroid nodules had a prevalence of 10%. Conclusion: Routine clinical reporting of incidental thyroid nodules is far less common than on dedicated review. Impact: These data contradict the notion that incidentalomas contribute significantly to rising thyroid cancer rates. Cancer Epidemiol Biomarkers Prev; 24(9); 1327–31. ©2015 AACR.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc5d9801863e53146dd0b6072371768Test
https://doi.org/10.1158/1055-9965.epi-15-0292Test -
2
المؤلفون: Peter Angelos, Brian C.-H. Chiu, Edwin L. Kaplan, Briseis Aschebrook-Kilfoy, Ya Chen Tina Shih, Raymon H. Grogan, Rebecca B. Schechter
المصدر: Cancer Epidemiology, Biomarkers & Prevention. 22:1252-1259
مصطلحات موضوعية: Adult, Male, Pathology, medicine.medical_specialty, Epidemiology, MEDLINE, Papillary thyroid cancer, Sex Factors, Cost of Illness, Environmental health, Epidemiology of cancer, medicine, Humans, Thyroid Neoplasms, Thyroid cancer, health care economics and organizations, business.industry, Incidence, Incidence (epidemiology), Thyroid, Cancer, Health Care Costs, Middle Aged, medicine.disease, United States, medicine.anatomical_structure, Oncology, Costs and Cost Analysis, Etiology, Female, business, SEER Program
الوصف: Background: Thyroid cancer incidence is increasing worldwide at an alarming rate, yet little is known of the impact this increase will have on society. We sought to determine the clinical and economic burden of a sustained increase in thyroid cancer incidence in the United States and to understand how these burdens correlate with the National Cancer Institute's (NCI) prioritization of thyroid cancer research funding. Methods: We used the NCI's SEER 13 database (1992–2009) and Joinpoint regression software to identify the current clinical burden of thyroid cancer and to project future incidence through 2019. We combined Medicare reimbursement rates with American Thyroid Association guidelines, and our clinical practice to create an economic model of thyroid cancer. We obtained research-funding data from the NCI's Office of Budget and Finance. Results; By 2019, papillary thyroid cancer will double in incidence and become the third most common cancer in women of all ages at a cost of $18 to $21 billion dollars in the United States. Despite these substantial clinical and economic burdens, thyroid cancer research remains significantly underfunded by comparison, and in 2009 received only $14.7 million (ranked 30th) from the NCI. Conclusion: The impact of thyroid cancer on society has been significantly underappreciated, as is evidenced by its low priority in national research funding levels. Impact: Increased awareness in the medical community and the general public of the societal burden of thyroid cancer, and substantial increases in research on thyroid cancer etiology, prevention, and treatment are needed to offset these growing concerns. Cancer Epidemiol Biomarkers Prev; 22(7); 1252–9. ©2013 AACR.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c60726b7df03c1d1441c03378039b8c9Test
https://doi.org/10.1158/1055-9965.epi-13-0242Test -
3
المصدر: Cancer Research. 78:4251-4251
مصطلحات موضوعية: Cancer Research, Oncology, Environmental health, Sociology, Health equity
الوصف: Background: Chicago has become the focus of national concern following findings of striking disparities in cancer incidence and mortality, with worse outcomes for Non-Hispanic Black persons. Chicago also has communities with very high crime rates, racial/ethnic segregation, and resource-poor communities. Social stressors, including crime, social isolation, low socioeconomic status (SES), interpersonal and institutional discrimination, and residence in resource-poor settings intersect at individual- and neighborhood- levels across the lifespan and are associated with poor health outcomes. However, the extent to which these social determinants separately and together contribute to cancer health disparities is unclear. Purpose: To elucidate health disparities attributable to neighborhood social stressors in the Chicago setting, a pilot Chicago Neighborhood Data System (ChNDS) is currently in production, using the Chicago Police Department crimes database, data from the 2010 Census short form, 2008-2012 American Community Survey (ACS), University of Chicago MAPSCorps project, and Environmental Systems Research Institute (ESRI) geodatabases. Approach: We use principal components analysis (PCA) to generate composite indices of neighborhood-level factors at the small area level (census tract or block group): racial/ethnic composition; SES; immigration/ acculturation; other sociodemographic characteristics; crime; and community assets including density/proximity to types of businesses, retail food, and recreational facilities. Future directions: Data record linkages at the small area-level will be performed between the pilot ChNDS and observational and population-based datasets to examine the impact of neighborhood-level characteristics on research study participation, disease occurrence, healthcare utilization, and disease outcomes in Chicago. Citation Format: David J. Press, Scarlett Lin Gomez, Briseis Aschebrook-Kilfoy, Habibul Ahsan. Neighborhood data system to enable health disparities research in Chicago [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 4251.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::f0b814ed5c849d45ca02d7854ed64288Test
https://doi.org/10.1158/1538-7445.am2018-4251Test
