Leukotriene B4 Creates a Favorable Microenvironment for Murine Melanoma Growth
| العنوان: | Leukotriene B4 Creates a Favorable Microenvironment for Murine Melanoma Growth |
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| المؤلفون: | S. Nonogaki, José Daniel Lopes, André Luis Lacerda Bachi, Célia Regina Whitaker Carneiro, Miriam Galvonas Jasiulionis, Mariangela Correa, Fabiana Jin Kyung Kim |
| المصدر: | Molecular Cancer Research. 7:1417-1424 |
| بيانات النشر: | American Association for Cancer Research (AACR), 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Lipopolysaccharides, Cancer Research, Leukotriene B4, Indomethacin, Apoptosis, Inflammation, Cell Growth Processes, Carrageenan, Mice, chemistry.chemical_compound, Cell Line, Tumor, medicine, Animals, Lipoxygenase Inhibitors, Melanoma, Molecular Biology, Tumor microenvironment, Leukotriene, Arachidonate 5-Lipoxygenase, biology, Histocytochemistry, medicine.disease, Eicosapentaenoic Acid, Oncology, chemistry, Prostaglandin-Endoperoxide Synthases, Tumor progression, Arachidonate 5-lipoxygenase, Disease Progression, biology.protein, Cancer research, Arachidonic acid, medicine.symptom |
| الوصف: | Chronic inflammation has long been associated with neoplastic progression. Our group had recently shown that the addition of a large number of apoptotic tumor cells to the tumor microenvironment induces a potent acute inflammatory reaction capable of promoting melanoma growth; however, primarily necrotizing cells do not cause such a reaction. Here, we show that potent inflammatory agents, such as lipopolysaccharide (LPS) and carrageenan, also promote growth of subtumorigenic doses of melanoma cells, having no effect on melanoma proliferation in vitro. Inhibition of 5-lipoxygenase (5-LOX) seems to have a pivotal role in this model because caffeic acid and MK886, a FLAP (5-LOX–activating protein) inhibitor, partially hindered tumor growth induced by apoptotic cells or LPS. Other enzymes of the arachidonic acid pathway, cyclooxygenase-1 and cyclooxygenase-2, seem to have no participation in this tumor promoter effect, as the inhibitor of both enzymes (indomethacin) did not alter melanoma growth. Leukotriene B4 (LTB4), the main product of the 5-LOX pathway, was able to induce growth of subtumorigenic inocula of melanoma cells, and a LTB4 receptor antagonist inhibited acute inflammation-associated tumor growth. Addition to the tumor inflammatory microenvironment of eicosapentaenoic acid, an ω3-polyunsaturated fatty acid with anti-inflammatory properties, or leukotriene B5, an eicosapentaenoic acid–derived leukotriene, significantly inhibited tumor development. These results give new insights to the mechanisms through which inflammation may contribute to tumor progression and suggest that LOX has an important role in tumor progression associated with an inflammatory state in the presence of apoptosis, which may be a consideration for apoptosis-inducing treatments, such as chemotherapy and radiotherapy. (Mol Cancer Res 2009;7(9):1417–24) |
| تدمد: | 1557-3125 1541-7786 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e80a466b8523c64532a0eda5bac655dTest https://doi.org/10.1158/1541-7786.mcr-09-0038Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3e80a466b8523c64532a0eda5bac655d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15573125 15417786 |
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