Breast cancer, dermatofibromas and arsenic
| العنوان: | Breast cancer, dermatofibromas and arsenic |
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| المؤلفون: | Paul I. Dantzig |
| المصدر: | Indian Journal of Dermatology |
| بيانات النشر: | American Association for Cancer Research (AACR), 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Oncology, Cancer Research, Pathology, medicine.medical_specialty, dermatofibromas, chemistry.chemical_element, Dermatology, Malignancy, Arsenic, breast cancer, Breast cancer, Internal medicine, Medicine, ARSENIC EXPOSURE, Arsenic toxicity, business.industry, Cancer, medicine.disease, Hyperpigmentation, chemistry, Hemosiderin, Etiology, Original Article, medicine.symptom, business |
| الوصف: | Abstract #4160 Background: Dermatofibromas are common benign tumors in women and breast cancer is the most common malignancy in women and an environmental etiology has been suspected in both conditions. The aim of this study is to determine if there is any relationship between the two conditions. Materials and Methods: 5 patients with dermatofibromas and 10 control patients(2 groups) had blood arsenic levels and their skin biopsies measured for arsenic by inductively coupled mass spectometry. Fifty randomly selected patients with breast cancer and 50 control patients were examined for the presence of dermatofibromas. Results: The patients with dermatofibromas had no detectable blood arsenic but the dermatofibromas were found to have an arsenic concentration of .171 micrograms/gram. One control group(5 patients) with no detectable blood arsenic had a skin concentration of .07 micrograms/gram and the other control group (5 patients) with an average blood concentration of 6 micrograms/liter had a concentration in their skin of .06 micrograms/gram. 43/50 patients with breast cancer had dermatofibromas and 32/50 had multiple dermatofibromas, compared with 10/50 control patients with dermatofibromas and only 1/50 with multiple dermatofibromas. In all breast cancer patients, the dermatofibromas preceded the breast cancer by many years though none of the patients could give an exact answer to that question. Conclusions: Dermatofibromas may represent a reservoir for arsenic and may interfere with the rapid excretion of arsenic resulting in prolonged exposure. Arsenic may be important to the development of dermatofibromas as shown by the proliferation of endothelial cells, the main target of arsenic toxicity, and the increased melanin and hemosiderin, the classic causes of hyperpigmentation in chronic arsenic toxicity.Dermatofibromas represent a sign of chronic arsenic exposure, a powerful environmental carcinogen, 5-20 years prior to the clinical signs of breast cancer, when the changes in the cells would first be developing. This is the first time that any link to an environmental carcinogen has been shown in breast cancer and may represent an important venue to dramatically decrease the number of cases in the future. The dermatofibroma, especially multiple dermatofibromas, represent an important cutaneous sign of women at risk for breast cancer. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 4160. |
| تدمد: | 1538-7445 0008-5472 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931ab652e4d24b4cc62cbbcea32b21dfTest https://doi.org/10.1158/0008-5472.sabcs-4160Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....931ab652e4d24b4cc62cbbcea32b21df |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15387445 00085472 |
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