Somatic Mutations of EGFR Gene in Squamous Cell Carcinoma of the Head and Neck
| العنوان: | Somatic Mutations of EGFR Gene in Squamous Cell Carcinoma of the Head and Neck |
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| المؤلفون: | Suk Woo Nam, Ja June Jang, Sug Hyung Lee, Jong Woo Lee, Min-Sik Kim, Dong Il Sun, Young Hwa Soung, Won Sang Park, Jung Young Lee, Su Young Kim, Nam Jin Yoo, Youn Soo Lee, Hyo Kyung Nam |
| المصدر: | Clinical Cancer Research. 11:2879-2882 |
| بيانات النشر: | American Association for Cancer Research (AACR), 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Adult, Male, Cancer Research, medicine.drug_class, DNA Mutational Analysis, Gene mutation, medicine.disease_cause, Tyrosine-kinase inhibitor, Germline mutation, Gefitinib, medicine, Humans, Epidermal growth factor receptor, Lung cancer, Polymorphism, Single-Stranded Conformational, Aged, Mutation, Base Sequence, biology, DNA, Neoplasm, Middle Aged, medicine.disease, ErbB Receptors, stomatognathic diseases, Oncology, Epidermoid carcinoma, Head and Neck Neoplasms, Carcinoma, Squamous Cell, Cancer research, biology.protein, Female, medicine.drug |
| الوصف: | Purpose: Recently, the kinase domain mutations of epidermal growth factor receptor (EGFR) gene have been identified in non–small-cell lung cancer, and these mutations have been related to the clinical response to the tyrosine kinase inhibitor gefitinib. Gefitinib treatment has also shown clinical benefits in squamous cell carcinoma of the head and neck (SCCHN). The aim of this study was to explore the possibility that SCCHN harbored the EGFR mutations. Experimental Design: In this study, we analyzed EGFR gene in 41 SCCHN for the detection of the somatic mutations by PCR-single-strand conformational polymorphism analysis. Results: Overall, we detected three EGFR mutations (7.3%), and all of the mutations were the same in-frame deletion mutation in exon 19 (E746_A750del). Conclusion: These data indicated that in addition to non–small-cell lung cancer, SCCHN harbors the EGFR gene mutations, and suggested the rationale for the clinical applicability of gefinitib to SCCHN patients. |
| تدمد: | 1557-3265 1078-0432 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32d044d8e82c6440b7d4b5eb1f956fffTest https://doi.org/10.1158/1078-0432.ccr-04-2029Test |
| رقم الانضمام: | edsair.doi.dedup.....32d044d8e82c6440b7d4b5eb1f956fff |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15573265 10780432 |
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