نتائج البحث - "Mice, SCID"

1

Inhibition of PIM Kinases in DLBCL Targets MYC Transcriptional Program and Augments the Efficacy of Anti-CD20 Antibodies

المصدر: Cancer Research. 81:6029-6043

مصطلحات موضوعية: Cancer Research, PIM1, Apoptosis, Mice, SCID, PLK1, Proto-Oncogene Proteins c-myc, Mice, 03 medical and health sciences, Antineoplastic Agents, Immunological, 0302 clinical medicine, Proto-Oncogene Proteins c-pim-1, immune system diseases, hemic and lymphatic diseases, Tumor Cells, Cultured, medicine, Animals, Humans, MCL1, Phosphorylation, Protein Kinase Inhibitors, Cell Proliferation, 030304 developmental biology, CD20, 0303 health sciences, biology, Kinase, Chemistry, Antigens, CD20, medicine.disease, Xenograft Model Antitumor Assays, 3. Good health, Lymphoma, Gene Expression Regulation, Neoplastic, Oncology, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Female, Lymphoma, Large B-Cell, Diffuse, Rituximab, Diffuse large B-cell lymphoma

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b037f71abd1b8eb257e3039012984508Test
https://doi.org/10.1158/0008-5472.can-21-1023Test

2

Differential Regulation of Cancer Progression by CDK4/6 Plays a Central Role in DNA Replication and Repair Pathways

المؤلفون: Alaa Moamer, Sergio A. Burgos, Ni Wang, Meiou Dai, Gang Yan, Jean-Jacques Lebrun, Suhad Ali, Siham Sabri, Julien Boudreault, Sophie Poulet, Girija Daliah

المصدر: Cancer Research. 81:1332-1346

مصطلحات موضوعية: DNA Replication, Male, 0301 basic medicine, Cancer Research, Lung Neoplasms, DNA Repair, DNA damage, medicine.medical_treatment, Breast Neoplasms, Mice, SCID, Biology, Metastasis, Targeted therapy, Gene Knockout Techniques, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, Neoplasms, medicine, Animals, Humans, CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats, Kinase, DNA replication, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinase 6, medicine.disease, Xenograft Model Antitumor Assays, Primary tumor, 3. Good health, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Female, Cyclin-dependent kinase 6, RNA, Guide, Kinetoplastida

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b04945d156b537d891cc0621339bd6Test
https://doi.org/10.1158/0008-5472.can-20-2121Test

3

YAP/TAZ Transcriptional Coactivators Create Therapeutic Vulnerability to Verteporfin in EGFR-mutant Glioblastoma

المؤلفون: Krishanthan Vigneswaran, Shoeb Lallani, Renee Read, Nathaniel H. Boyd, Andrew B. Boucher, Se-Yeong Oh, Stewart G. Neill, Jeffrey J. Olson

المصدر: Clin Cancer Res

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Apoptosis, Cell Cycle Proteins, Mice, SCID, Article, Receptor tyrosine kinase, Mice, 03 medical and health sciences, 0302 clinical medicine, SOX2, Mice, Inbred NOD, Glioma, Biomarkers, Tumor, Tumor Cells, Cultured, medicine, Animals, Humans, Progenitor cell, Cell Proliferation, Gene knockdown, Hippo signaling pathway, Photosensitizing Agents, biology, Verteporfin, Prognosis, medicine.disease, Xenograft Model Antitumor Assays, nervous system diseases, ErbB Receptors, Gene Expression Regulation, Neoplastic, Drosophila melanogaster, 030104 developmental biology, Oncology, Transcriptional Coactivator with PDZ-Binding Motif Proteins, 030220 oncology & carcinogenesis, Mutation, Neoplastic Stem Cells, biology.protein, Cancer research, Female, Stem cell, Glioblastoma, Transcription Factors, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::996855d7a90a5bd44b77418fe2c7a107Test
https://doi.org/10.1158/1078-0432.ccr-20-0018Test

4

Activation of Receptor Tyrosine Kinases Mediates Acquired Resistance to MEK Inhibition in Malignant Peripheral Nerve Sheath Tumors

المؤلفون: Jiawan Wang, Ana Calizo, Christine A. Pratilas, Kai Pollard

المصدر: Cancer Res

مصطلحات موضوعية: Proteomics, 0301 basic medicine, Cancer Research, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Mice, SCID, medicine.disease_cause, Nerve Sheath Neoplasms, Receptor tyrosine kinase, Mice, Random Allocation, 0302 clinical medicine, Mice, Inbred NOD, Medicine, Neurofibromin 1, biology, Hepatocyte Growth Factor, Effector, TOR Serine-Threonine Kinases, MEK inhibitor, Proto-Oncogene Proteins c-met, Up-Regulation, Oncology, 030220 oncology & carcinogenesis, Female, Sarcoma, Signal Transduction, Neurofibromatosis 1, MAP Kinase Signaling System, Pyridones, Antineoplastic Agents, Pyrimidinones, Article, Receptor, Platelet-Derived Growth Factor beta, 03 medical and health sciences, Acquired resistance, Cell Line, Tumor, Peripheral Nerve Sheath Tumors, Animals, Humans, Neurofibromatosis, Protein Kinase Inhibitors, business.industry, Receptor Protein-Tyrosine Kinases, medicine.disease, Enzyme Activation, Proto-Oncogene Proteins c-raf, 030104 developmental biology, Drug Resistance, Neoplasm, ras Proteins, biology.protein, Cancer research, Neoplasm Recurrence, Local, business, Carcinogenesis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8da78451f9d92c566e3cd98829de844Test
https://doi.org/10.1158/0008-5472.can-20-1992Test

5

HDP-101, an Anti-BCMA Antibody–Drug Conjugate, Safely Delivers Amanitin to Induce Cell Death in Proliferating and Resting Multiple Myeloma Cells

المؤلفون: Carsten Müller-Tidow, Christoph Müller, Anikó Pálfi, Alwin Krämer, Torsten Hechler, Hartmut Goldschmidt, Vianihuini Figueroa-Vazquez, Marc S. Raab, Michael Kulke, Christian Breunig, Nicola Giesen, Jonathan Ko, Andreas Pahl, Anja Baumann, Christian Lutz

المصدر: Molecular Cancer Therapeutics. 20:367-378

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc4bada6ec5e1d93000278d5ab727acfTest
https://doi.org/10.1158/1535-7163.mct-20-0287Test

6

Oncolytic HSV Therapy Modulates Vesicular Trafficking Inducing Cisplatin Sensitivity and Antitumor Immunity

المؤلفون: Zahid H. Siddik, Bangxing Hong, Uksha Saini, David E. Cohn, Anil K. Sood, Guangsheng Pei, Guangan He, Zhongming Zhao, Yuanqing Yan, Karuppaiyah Selvendiran, Valerie Chapa, Balveen Kaur, Ji Young Yoo, Puneet Modgil

المصدر: Clin Cancer Res

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, medicine.medical_treatment, Antineoplastic Agents, Herpesvirus 1, Human, Mice, SCID, Article, DNA Adducts, 03 medical and health sciences, 0302 clinical medicine, Immune system, Mice, Inbred NOD, Cell Line, Tumor, medicine, Animals, Humans, Cells, Cultured, Mice, Knockout, Oncolytic Virotherapy, Ovarian Neoplasms, Cisplatin, Innate immune system, biology, business.industry, Immunotherapy, Extracellular vesicle, Combined Modality Therapy, Xenograft Model Antitumor Assays, Immune checkpoint, Oncolytic virus, Mice, Inbred C57BL, Disease Models, Animal, Treatment Outcome, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, biology.protein, Cancer research, Female, Antibody, business, Signal Transduction, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65ac801d5e7fe6aafe0687c5a55db37cTest
https://doi.org/10.1158/1078-0432.ccr-20-2210Test

7

Exogenous Thyroid Hormone Is Associated with Shortened Survival and Upregulation of High-Risk Gene Expression Profiles in Steroid Receptor–Positive Breast Cancers

المؤلفون: Britta M. Jacobsen, Jessica Finlay-Schultz, Reema Wahdan-Alaswad, Susan M. Edgerton, Bryan R. Haugen, Hyunmin Kim, Carol A. Sartorius, Elizabeth A. Wellberg, Ann D. Thor, Bolin Liu, Aik Choon Tan, Hiba Salem

المصدر: Clinical Cancer Research. 27:585-597

مصطلحات موضوعية: Oncology, Thyroid Hormones, Cancer Research, medicine.medical_specialty, Antineoplastic Agents, Hormonal, Hormone Replacement Therapy, medicine.drug_class, Estrogen receptor, Breast Neoplasms, 030209 endocrinology & metabolism, Kaplan-Meier Estimate, Mice, SCID, Disease-Free Survival, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Mice, Inbred NOD, Cell Line, Tumor, Internal medicine, medicine, Animals, Humans, Aromatase, Mice, Knockout, Thyroid hormone receptor, biology, business.industry, Thyroid disease, medicine.disease, Xenograft Model Antitumor Assays, Up-Regulation, Tamoxifen, Receptors, Estrogen, Estrogen, 030220 oncology & carcinogenesis, MCF-7 Cells, biology.protein, Female, Transcriptome, business, medicine.drug, Hormone

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be5c776fe13cc174a74a981e7ae8d534Test
https://doi.org/10.1158/1078-0432.ccr-20-2647Test

8

CD19-specific CAR T Cells that Express a PD-1/CD28 Chimeric Switch-Receptor are Effective in Patients with PD-L1–positive B-Cell Lymphoma

المؤلفون: Juying Wei, Ken H. Young, Wenbin Qian, Ying Lu, Chaoting Zhang, Chunmei Yang, Wen Lei, Qunyi Guo, Hui Liu, Zhilu Chen, Xiaojun Guo, Zheming Lu

المصدر: Clinical Cancer Research. 27:473-484

مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, T-Lymphocytes, medicine.medical_treatment, Programmed Cell Death 1 Receptor, Receptors, Antigen, T-Cell, chemical and pharmacologic phenomena, Kaplan-Meier Estimate, Mice, SCID, Immunotherapy, Adoptive, B7-H1 Antigen, CD19, 03 medical and health sciences, 0302 clinical medicine, CD28 Antigens, Mice, Inbred NOD, immune system diseases, Cell Line, Tumor, hemic and lymphatic diseases, medicine, Animals, Humans, B-cell lymphoma, Mice, Knockout, Receptors, Chimeric Antigen, biology, business.industry, CD28, hemic and immune systems, Leukopenia, Middle Aged, medicine.disease, Xenograft Model Antitumor Assays, Chimeric antigen receptor, Lymphoma, Cytokine release syndrome, Treatment Outcome, 030104 developmental biology, Cytokine, Oncology, Tolerability, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Female, Lymphoma, Large B-Cell, Diffuse, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2c21a906a2bd6b1e713cb5db998726eTest
https://doi.org/10.1158/1078-0432.ccr-20-1457Test

9

TriTACs, a Novel Class of T-Cell–Engaging Protein Constructs Designed for the Treatment of Solid Tumors

المصدر: Molecular Cancer Therapeutics. 20:109-120

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7405941cbbfa5d733a65e82cb28cafa8Test
https://doi.org/10.1158/1535-7163.mct-20-0061Test

10

Targeting Oncogene mRNA Translation in B-Cell Malignancies with eFT226, a Potent and Selective Inhibitor of eIF4A

المصدر: Molecular Cancer Therapeutics. 20:26-36

مصطلحات موضوعية: 0301 basic medicine, Untranslated region, Cancer Research, Lymphoma, B-Cell, Mice, SCID, medicine.disease_cause, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Mice, Inbred NOD, In vivo, Cell Line, Tumor, Biomarkers, Tumor, medicine, Animals, Humans, PTEN, RNA, Messenger, EIF4B, Protein kinase B, PI3K/AKT/mTOR pathway, biology, EIF4G, TOR Serine-Threonine Kinases, PTEN Phosphohydrolase, Oncogenes, Xenograft Model Antitumor Assays, 030104 developmental biology, Oncology, chemistry, Drug Resistance, Neoplasm, Protein Biosynthesis, 030220 oncology & carcinogenesis, Eukaryotic Initiation Factor-4A, biology.protein, Cancer research, Female, Carcinogenesis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c14e9801128ca86bd9b7b59cc4c5bb4eTest
https://doi.org/10.1158/1535-7163.mct-19-0973Test

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