Circulating tumor and immune cells for minimally invasive risk stratification of smoldering multiple myeloma
| العنوان: | Circulating tumor and immune cells for minimally invasive risk stratification of smoldering multiple myeloma |
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| المؤلفون: | Termini, Rosalinda, Zihala, David, Terpos, Evangelos, Perez-Montana, Albert, Jelinek, Tomas, Raab, Marc, Weinhold, Niels, Mai, Elias K, Grab, Anna Luise, Corre, Jill, Vergez, Francois, Sacco, Antonio, Chiarini, Marco, Giustini, Viviana, Tucci, Alessandra, Rodriguez, Sara, Moreno, Cristina, Perez, Cristina, Maia, Catarina, Martin-Sanchez, Esperanza, Guerrero, Camila, Botta, Cirino, Garces, Juan-Jose, Lopez, Aitziber, Tamariz-Amador, Luis-Esteban, Prosper, Felipe, Bargay, Joan, Cabezudo, Maria-Elena, Ocio, Enrique M, Hajek, Roman, Martinez-Lopez, Joaquin, Solano, Fernando, Iglesias, Rebeca, Paiva, Artur, Geraldes, Catarina, Matos Silva, Helena, Gomez, Clara, De Arriba, Felipe, Ludwig, Heinz, Garcia-Guinon, Antoni, Casanova, Maria, Alegre, Adrian, Cabanas, Valentin, Sirvent, Maialen, Oriol, Albert, de la Rubia, Javier, Hernandez-Rivas, Jose-Angel, Palomera, Luis, Sarasa, Maria, Rios, Pablo, Puig, Noemi, Mateos, Maria-Victoria, Flores-Montero, Juan, Orfao, Alberto, Goldschmidt, Hartmut, Avet-Loiseau, Herve, Roccaro, Aldo M, San-Miguel, Jesus F, Paiva, Bruno |
| المساهمون: | Termini, Rosalinda, Zihala, David, Terpos, Evangelo, Pérez-Montaña, Albert, Jelinek, Toma, Raab, Marc, Weinhold, Niel, Mai, Elias K, Grab, Anna Luise, Corre, Jill, Vergez, Francoi, Sacco, Antonio, Chiarini, Marco, Giustini, Viviana, Tucci, Alessandra, Rodríguez, Sara, Moreno, Cristina, Perez, Cristina, Maia, Catarina, Martin-Sanchez, Esperanza, Guerrero, Camila, Botta, Cirino, Garcés, Juan-Jose, Lopez, Aitziber, Tamariz-Amador, Luis-Esteban, Prósper, Felipe, Bargay, Joan, Cabezudo, Maria-Elena, Ocio, Enrique M, Hájek, Roman, Martinez-Lopez, Joaquin, Solano, Fernando, Iglesias, Rebeca, Paiva, Artur, Geraldes, Catarina, Matos Silva, Helena, Gomez, Clara, De Arriba, Felipe, Ludwig, Heinz, Garcia-Guiñon, Antoni, Casanova, Maria, Alegre, Adrian, Cabañas, Valentin, Sirvent, Maialen, Oriol, Albert, De la Rubia, Javier, Hernández-Rivas, José-Ángel, Palomera, Lui, Sarasa, Maria, Rios, Pablo, Puig, Noemi, Mateos, Maria-Victoria, Flores-Montero, Juan, Orfao, Alberto, Goldschmidt, Hartmut, Avet-Loiseau, Herve, Roccaro, Aldo M, San-Miguel, Jesus F, Paiva, Bruno |
| المصدر: | Clinical cancer research : an official journal of the American Association for Cancer Research r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname |
| بيانات النشر: | American Association for Cancer Research, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Smoldering Multiple Myeloma, Cancer Research, myeloma, Oncology, Disease Progression, Humans, Immunoglobulin Light Chains, Prognosis, Multiple Myeloma, Risk Assessment, circulating tumor cell, immune profile |
| الوصف: | Purpose: Early intervention in smoldering multiple myeloma (SMM) requires optimal risk stratification to avoid under- and overtreatment. We hypothesized that replacing bone marrow (BM) plasma cells (PC) for circulating tumor cells (CTC), and adding immune biomarkers in peripheral blood (PB) for the identification of patients at risk of progression due to lost immune surveillance, could improve the International Myeloma Working Group 20/2/20 model. Experimental Design: We report the outcomes of 150 patients with SMM enrolled in the iMMunocell study, in which serial assessment of tumor and immune cells in PB was performed every 6 months for a period of 3 years since enrollment. Results: Patients with >0.015% versus ≤0.015% CTCs at baseline had a median time-to-progression of 17 months versus not reached (HR, 4.9; P 20% BM PCs had no prognostic value in a multivariate analysis that included serum free light-chain ratio >20, >2 g/dL M-protein, and >0.015% CTCs. The 20/2/20 and 20/2/0.015 models yielded similar risk stratification (C-index of 0.76 and 0.78). The combination of the 20/2/0.015 model with an immune risk score based on the percentages of SLAN+ and SLAN− nonclassical monocytes, CD69+HLADR+ cytotoxic NK cells, and CD4+CXCR3+ stem central memory T cells, allowed patient’ stratification into low, intermediate-low, intermediate-high, and high-risk disease with 0%, 20%, 39%, and 73% rates of progression at 2 years. Conclusions: This study showed that CTCs outperform BM PCs for assessing tumor burden. Additional analysis in larger series are needed to define a consensus cutoff of CTCs for minimally invasive stratification of SMM. |
| تدمد: | 1557-3265 1078-0432 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ff52cdd72f2b776b5805e7e201bfa32Test http://hdl.handle.net/10261/296559Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3ff52cdd72f2b776b5805e7e201bfa32 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15573265 10780432 |
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