دورية أكاديمية
Induction of paracrine signaling in metastatic melanoma cells by PPARγ agonist rosiglitazone activates stromal cells and enhances tumor growth
| العنوان: | Induction of paracrine signaling in metastatic melanoma cells by PPARγ agonist rosiglitazone activates stromal cells and enhances tumor growth |
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| المؤلفون: | Pich, Christine, Meylan, Patrick, Mastelic-Gavillet, Beatris, Nguyen, Thanh Nhan, Loyon, Romain, Trang, Bao Khanh, Moser, Hélène, Moret, Catherine, Goepfert, Christine, Hafner, Jürg, Levesque, Mitchell P, Romero, Pedro, Jandus, Camilla, Michalik, Liliane |
| المصدر: | Pich, Christine; Meylan, Patrick; Mastelic-Gavillet, Beatris; Nguyen, Thanh Nhan; Loyon, Romain; Trang, Bao Khanh; Moser, Hélène; Moret, Catherine; Goepfert, Christine; Hafner, Jürg; Levesque, Mitchell P; Romero, Pedro; Jandus, Camilla; Michalik, Liliane (2018). Induction of paracrine signaling in metastatic melanoma cells by PPARγ agonist rosiglitazone activates stromal cells and enhances tumor growth. Cancer Research, 78(22):6447-6461. |
| بيانات النشر: | American Association for Cancer Research |
| سنة النشر: | 2018 |
| المجموعة: | University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
| مصطلحات موضوعية: | Dermatology Clinic, 610 Medicine & health, Cancer Research, Oncology |
| الوصف: | In addition to improving insulin sensitivity in type 2 diabetes, the thiazolidinedione family of compounds and the pharmacologic activation of their best-characterized target PPARγ have been proposed as a therapeutic option for cancer treatment. In this study, we reveal a new mode of action for the thiazolidinedione rosiglitazone that can contribute to tumorigenesis. Rosiglitazone activated a tumorigenic paracrine communication program in a subset of human melanoma cells that involves the secretion of cytokines, chemokines, and angiogenic factors. This complex blend of paracrine signals activated nonmalignant fibroblasts, endothelial cells, and macrophages in a tumor-friendly way. In agreement with these data, rosiglitazone promoted human melanoma development in xenografts, and tumors exposed to rosiglitazone exhibited enhanced angiogenesis and inflammation. Together, these findings establish an important tumorigenic action of rosiglitazone in a subset of melanoma cells. Although studies conducted on cohorts of diabetic patients report overall benefits of thiazolidinediones in cancer prevention, our data suggest that exposure of established tumors to rosiglitazone may be deleterious. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0008-5472 |
| العلاقة: | https://www.zora.uzh.ch/158449Test; info:pmid/30185551; urn:issn:0008-5472 |
| DOI: | 10.1158/0008-5472.can-18-0912 |
| الإتاحة: | https://doi.org/10.1158/0008-5472.can-18-0912Test https://www.zora.uzh.ch/id/eprint/158449Test/ https://www.zora.uzh.ch/158449Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.ED34C6F7 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 00085472 |
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| DOI: | 10.1158/0008-5472.can-18-0912 |