Patients with obstructive sleep apnea present with chronic upregulation of serum HIF-1α protein
| العنوان: | Patients with obstructive sleep apnea present with chronic upregulation of serum HIF-1α protein |
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| المؤلفون: | Marcin Sochal, Robert Stawski, Janusz Szemraj, Bartosz Szmyd, Piotr Białasiewicz, Agata Gabryelska |
| المصدر: | J Clin Sleep Med |
| بيانات النشر: | American Academy of Sleep Medicine (AASM), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Pulmonary and Respiratory Medicine, medicine.medical_specialty, Chronic condition, Polysomnography, Hypoxemia, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Internal medicine, Humans, Medicine, Hypoxia, Sleep Apnea, Obstructive, business.industry, Intermittent hypoxia, Blood Proteins, Hypoxia (medical), medicine.disease, Scientific Investigations, Up-Regulation, respiratory tract diseases, Obstructive sleep apnea, Neurology, Cardiology, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery |
| الوصف: | STUDY OBJECTIVES: Obstructive sleep apnea (OSA) is a chronic condition that is characterized by recurrent pauses in breathing during sleep causing intermittent hypoxia. The main factor responsible for oxygen metabolism homeostasis is hypoxia-inducible factor 1 (HIF-1), comprised of 2 subunits: α (oxygen sensitive) and β. The aim of the study was to investigate the HIF-1α serum protein level and mRNA HIF-1α expression in patients with OSA and a healthy control group and determine their evening-morning variation and association with polysomnography parameters. METHODS: Eighty-four individuals were enrolled in the study. All patients underwent polysomnography examination and based on the results were divided into 2 groups: OSA group (n = 60) and control group (n = 24). Peripheral blood was collected in the evening before and in the morning after the polysomnography. HIF-1α expression was evaluated on protein in blood serum and mRNA level in peripheral blood leukocytes. RESULTS: HIF-1α serum protein concentration was higher in patients with OSA compared with control patients in both the evening (1,490.1 vs. 727.0 pg/mL; P < .001) and the morning (1,368.9 vs. 702.1 pg/mL; P < .001) samples. There was no difference between evening and morning HIF-1α serum protein level in either group. No differences were observed in HIF-1α mRNA expression between the OSA and control group. Additionally, evening and morning HIF-1α serum protein level correlated with number of desaturations during sleep (r = .384, P < .001 and r = .433, P < .001, respectively). CONCLUSIONS: Observed differences in HIF-1α serum protein level between the OSA and the control groups without difference between evening and morning measurements suggest chronic increase in this protein concentration by intermittent nocturnal hypoxia in OSA. CITATION: Gabryelska A, Szmyd B, Szemraj J, Stawski R, Sochal M, Białasiewicz P. Patients with obstructive sleep apnea present with chronic upregulation of serum HIF-1α protein. J Clin Sleep Med. 2020;16(10):1761–1768. |
| تدمد: | 1550-9397 1550-9389 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::652bef9ea7013bb8cc7ffc5ab44c31fbTest https://doi.org/10.5664/jcsm.8682Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....652bef9ea7013bb8cc7ffc5ab44c31fb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15509397 15509389 |
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