Current Treatment of Juvenile Rheumatoid Arthritis
| العنوان: | Current Treatment of Juvenile Rheumatoid Arthritis |
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| المؤلفون: | Norman T. Ilowite |
| المصدر: | Pediatrics. 109:109-115 |
| بيانات النشر: | American Academy of Pediatrics (AAP), 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | musculoskeletal diseases, medicine.medical_specialty, Arthritis, Receptors, Tumor Necrosis Factor, Etanercept, Internal medicine, medicine, Animals, Humans, Rheumatoid factor, Child, skin and connective tissue diseases, Leflunomide, business.industry, Contraindications, Anti-Inflammatory Agents, Non-Steroidal, Antibodies, Monoclonal, Isoxazoles, medicine.disease, Arthritis, Juvenile, Infliximab, Sulfasalazine, Methotrexate, Antirheumatic Agents, Immunoglobulin G, Rheumatoid arthritis, Pediatrics, Perinatology and Child Health, Immunology, Celecoxib, business, Juvenile rheumatoid arthritis, medicine.drug |
| الوصف: | Prognostic factors in juvenile rheumatoid arthritis (JRA) include polyarticular onset, polyarticular disease course, and rheumatoid factor positivity; in the systemic onset subtype, persistence of systemic features at 6 months after onset confers a worse prognosis. Timely diagnosis and appropriate aggressive treatment of patients with poor prognostic features improve quality of life and outcome. After nonsteroidal anti-inflammatory drugs, methotrexate is the most commonly used second-line agent. However, approximately one third of patients do not respond to methotrexate adequately. Randomized, placebo-controlled, clinical trials in patients with JRA are few, but one such trial with the tumor necrosis factor inhibitor etanercept shows that this drug is effective and well-tolerated. Other recently approved agents for rheumatoid arthritis, including infliximab, leflunomide, celecoxib, and rofecoxib, have not been adequately studied in pediatric patients, and the role of these agents in children with JRA remains to be determined. |
| تدمد: | 1098-4275 0031-4005 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac549fcab5257a4c3b8a94cd50b8cbe3Test https://doi.org/10.1542/peds.109.1.109Test |
| رقم الانضمام: | edsair.doi.dedup.....ac549fcab5257a4c3b8a94cd50b8cbe3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10984275 00314005 |
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