Erythropoietin for Neuroprotection in Neonatal Encephalopathy: Safety and Pharmacokinetics
| العنوان: | Erythropoietin for Neuroprotection in Neonatal Encephalopathy: Safety and Pharmacokinetics |
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| المؤلفون: | Sandra E. Juul, Taeun Chang, Sonia L. Bonifacio, Dennis E. Mayock, Larry A. Bauer, David J. Durand, Hannah C. Glass, Yvonne W. Wu, David V. Glidden, Roberta A. Ballard, Donna M. Ferriero, Dongli Song, Fernando F. Gonzalez |
| المصدر: | Pediatrics, vol 130, iss 4 Wu, YW; Bauer, LA; Ballard, RA; Ferriero, DM; Glidden, DV; Mayock, DE; et al.(2012). Erythropoietin for neuroprotection in neonatal encephalopathy: Safety and pharmacokinetics. Pediatrics, 130(4), 683-691. doi: 10.1542/peds.2012-0498. UCSF: Retrieved from: http://www.escholarship.org/uc/item/0dz943q0Test |
| بيانات النشر: | American Academy of Pediatrics, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Male, Resuscitation, Hypothermia, Neurodegenerative, Medical and Health Sciences, Pediatrics, Hypothermia, Induced, Infant Mortality, Medicine, Infusions, Intravenous, Pediatric, neonatal encephalopathy, Area under the curve, Brain, Hematology, asphyxia, Combined Modality Therapy, Neuroprotective Agents, 6.1 Pharmaceuticals, Anesthesia, Hypoxia-Ischemia, Brain, neuroprotection, Apgar score, Female, Drug, medicine.symptom, Intravenous, medicine.drug, Half-Life, Infusions, Physical Injury - Accidents and Adverse Effects, Metabolic Clearance Rate, Cmax, Article, Drug Administration Schedule, Dose-Response Relationship, Pharmacokinetics, Clinical Research, Hypoxia-Ischemia, Humans, Erythropoietin, Analysis of Variance, Dose-Response Relationship, Drug, business.industry, Neonatal encephalopathy, Induced, Psychology and Cognitive Sciences, Neurosciences, Infant, Newborn, Infant, Evaluation of treatments and therapeutic interventions, Perinatal Period - Conditions Originating in Perinatal Period, Newborn, medicine.disease, Pediatrics, Perinatology and Child Health, business |
| الوصف: | OBJECTIVE: To determine the safety and pharmacokinetics of erythropoietin (Epo) given in conjunction with hypothermia for hypoxic-ischemic encephalopathy (HIE). We hypothesized that high dose Epo would produce plasma concentrations that are neuroprotective in animal studies (ie, maximum concentration = 6000–10 000 U/L; area under the curve = 117 000–140 000 U*h/L). METHODS: In this multicenter, open-label, dose-escalation, phase I study, we enrolled 24 newborns undergoing hypothermia for HIE. All patients had decreased consciousness and acidosis (pH < 7.00 or base deficit ≥ 12), 10-minute Apgar score ≤ 5, or ongoing resuscitation at 10 minutes. Patients received 1 of 4 Epo doses intravenously: 250 ( N = 3), 500 ( N = 6), 1000 ( N = 7), or 2500 U/kg per dose ( N = 8). We gave up to 6 doses every 48 hours starting at |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69d439a1923f709f3f7b6650a6339049Test https://europepmc.org/articles/PMC3457622Test/ |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....69d439a1923f709f3f7b6650a6339049 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |