Celiac Disease Autoimmunity and Emotional and Behavioral Problems in Childhood
| العنوان: | Celiac Disease Autoimmunity and Emotional and Behavioral Problems in Childhood |
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| المؤلفون: | Pauline W. Jansen, Sytske A. Beth, Rama J. Wahab, Ivonne P M Derks, Henriette A. Moll, Jessica C. Kiefte-de Jong |
| المساهمون: | Pediatrics, Erasmus MC other, Child and Adolescent Psychiatry / Psychology, Clinical Psychology |
| المصدر: | Pediatrics, 144(4) Pediatrics, 144(4):e20183933. American Academy of Pediatrics |
| بيانات النشر: | American Academy of Pediatrics, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Pediatrics, medicine.medical_specialty, Population, CBCL, Disease, Anxiety, Sensitivity and Specificity, Autoimmune Diseases, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, GTP-Binding Proteins, HLA-DQ Antigens, 030225 pediatrics, Confidence Intervals, medicine, Humans, Protein Glutamine gamma Glutamyltransferase 2, Prospective Studies, Child, education, Child Behavior Checklist, Autoantibodies, Subclinical infection, Problem Behavior, education.field_of_study, Transglutaminases, business.industry, Infant, Checklist, Celiac Disease, Attention Deficit and Disruptive Behavior Disorders, Child, Preschool, Pediatrics, Perinatology and Child Health, Linear Models, Female, medicine.symptom, business, Cohort study, Psychopathology |
| الوصف: | BACKGROUND AND OBJECTIVES: Celiac disease (CeD) is associated with psychopathology in children. It is unknown whether this association is present in children with celiac disease autoimmunity (CDA) identified by screening. We examined the associations between subclinical CDA and emotional and behavioral problems in children without previous CeD diagnosis. METHODS: In a population-based cohort study of 3715 children (median age: 6 years), blood titers of tissue transglutaminase autoantibodies were analyzed. CDA was defined as a measurement of tissue transglutaminase autoantibodies ≥7 U/mL (n = 51). Children with previous CeD diagnosis or children on a gluten-free diet, were excluded. The Child Behavior Checklist (CBCL) was filled in by parents and was used to assess behavioral and emotional problems of children at a median age of 5.9 years. Multiple linear regression models were applied to evaluate the cross-sectional associations between CDA and CBCL scores. Sensitivity analyses were done in a subgroup of children who were seropositive carrying the HLA antigen risk alleles for CeD. RESULTS: In basic models, CDA was not associated with emotional and behavioral problems on the CBCL scales. After adjustment for confounders, CDA was significantly associated with anxiety problems (β = .29; 95% confidence interval 0.02 to 0.55; P = .02). After exclusion of children who did not carry the HLA-DQ2 and/or HLA-DQ8 risk alleles (n = 4), CDA was additionally associated with oppositional defiant problems (β = .35; 95% confidence interval 0.02 to 0.69). Associations were not explained by gastrointestinal complaints. CONCLUSIONS: Our results reveal that CDA, especially combined with the HLA-DQ2 and HLA-DQ8 risk alleles, is associated with anxiety problems and oppositional defiant problems. Further research should be used to establish whether behavioral problems are a reflection of subclinical CeD. |
| اللغة: | English |
| تدمد: | 1098-4275 0031-4005 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd34f0cc50b98c7adfd9990c9c42efe8Test https://pure.eur.nl/en/publications/9204e997-c6f3-4f96-b060-4510953f9a4bTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bd34f0cc50b98c7adfd9990c9c42efe8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10984275 00314005 |
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