دورية أكاديمية
Statin Therapy for Secondary Prevention in Ischemic Stroke Patients With Cerebral Microbleeds.
| العنوان: | Statin Therapy for Secondary Prevention in Ischemic Stroke Patients With Cerebral Microbleeds. |
|---|---|
| المؤلفون: | Prats-Sanchez, Luis, Camps-Renom, Pol, Nash, Philip S, Wilson, Duncan, Ambler, Gareth, Best, Jonathan G, Guasch-Jiménez, Marina, Ramos-Pachón, Anna, Martinez-Domeño, Alejandro, Lambea-Gil, Álvaro, Díaz, Garbiñe Ezcurra, Guisado-Alonso, Daniel, Du, Houwei, Al-Shahi Salman, Rustam, Jäger, Hans Rolf, Lip, Gregory Y, Ay, Hakan, Jung, Simon, Bornstein, Natan M, Gattringer, Thomas, Eppinger, Sebastian, van Dam-Nolen, Dianne H, Koga, Masatoshi, Toyoda, Kazunori, Fluri, Felix, Phan, Thanh G, Srikanth, Velandai K, Heo, Ji Hoe, Bae, Hee-Joon, Kelly, Peter J, Imaizumi, Toshio, Staals, Julie, Köhler, Sebastian, Yakushiji, Yusuke, Orken, Dilek Necioglu, Smith, Eric E, Wardlaw, Joanna M, Chappell, Francesca M, Makin, Stephen D, Mas, Jean-Louis, Calvet, David, Bordet, Régis, Chen, Christopher P, Veltkamp, Roland, Kandiah, Nagaendran, Simister, Robert J, De Leeuw, Frank-Erik, Engelter, Stefan T, Peters, Nils, Soo, Yannie O, Zietz, Annaelle, Hendrikse, Jeroen, Mess, Werner H, Werring, David J, Marti-Fabregas, Joan |
| المصدر: | Prats-Sanchez, Luis; Camps-Renom, Pol; Nash, Philip S; Wilson, Duncan; Ambler, Gareth; Best, Jonathan G; Guasch-Jiménez, Marina; Ramos-Pachón, Anna; Martinez-Domeño, Alejandro; Lambea-Gil, Álvaro; Díaz, Garbiñe Ezcurra; Guisado-Alonso, Daniel; Du, Houwei; Al-Shahi Salman, Rustam; Jäger, Hans Rolf; Lip, Gregory Y; Ay, Hakan; Jung, Simon; Bornstein, Natan M; Gattringer, Thomas; . (2024). Statin Therapy for Secondary Prevention in Ischemic Stroke Patients With Cerebral Microbleeds. Neurology, 102(7) American Academy of Neurology 10.1212/WNL.0000000000209173 |
| بيانات النشر: | American Academy of Neurology |
| سنة النشر: | 2024 |
| المجموعة: | BORIS (Bern Open Repository and Information System, University of Bern) |
| مصطلحات موضوعية: | 610 Medicine & health |
| الوصف: | BACKGROUND AND OBJECTIVES The association between statin use and the risk of intracranial hemorrhage (ICrH) following ischemic stroke (IS) or transient ischemic attack (TIA) in patients with cerebral microbleeds (CMBs) remains uncertain. This study investigated the risk of recurrent IS and ICrH in patients receiving statins based on the presence of CMBs. METHODS We conducted a pooled analysis of individual patient data from the Microbleeds International Collaborative Network, comprising 32 hospital-based prospective studies fulfilling the following criteria: adult patients with IS or TIA, availability of appropriate baseline MRI for CMB quantification and distribution, registration of statin use after the index stroke, and collection of stroke event data during a follow-up period of ≥3 months. The primary endpoint was the occurrence of recurrent symptomatic stroke (IS or ICrH), while secondary endpoints included IS alone or ICrH alone. We calculated incidence rates and performed Cox regression analyses adjusting for age, sex, hypertension, atrial fibrillation, previous stroke, and use of antiplatelet or anticoagulant drugs to explore the association between statin use and stroke events during follow-up in patients with CMBs. RESULTS In total, 16,373 patients were included (mean age 70.5 ± 12.8 years; 42.5% female). Among them, 10,812 received statins at discharge, and 4,668 had 1 or more CMBs. The median follow-up duration was 1.34 years (interquartile range: 0.32-2.44). In patients with CMBs, statin users were compared with nonusers. Compared with nonusers, statin therapy was associated with a reduced risk of any stroke (incidence rate [IR] 53 vs 79 per 1,000 patient-years, adjusted hazard ratio [aHR] 0.68 [95% CI 0.56-0.84]), a reduced risk of IS (IR 39 vs 65 per 1,000 patient-years, aHR 0.65 [95% CI 0.51-0.82]), and no association with the risk of ICrH (IR 11 vs 16 per 1,000 patient-years, aHR 0.73 [95% CI 0.46-1.15]). The results in aHR remained consistent when considering anatomical distribution and high ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://boris.unibe.ch/194195Test/ |
| الإتاحة: | https://doi.org/10.1212/WNL.0000000000209173Test https://boris.unibe.ch/194195/1/WNL.0000000000209173.pdfTest https://boris.unibe.ch/194195Test/ |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.CFCE426B |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |