دورية أكاديمية
Neutralizing antibodies against autologous human immunodeficiency virus type 1 isolates in patients with increasing CD4 cell counts despite incomplete virus suppression during antiretroviral treatment
| العنوان: | Neutralizing antibodies against autologous human immunodeficiency virus type 1 isolates in patients with increasing CD4 cell counts despite incomplete virus suppression during antiretroviral treatment |
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| المؤلفون: | SARMATI, LOREDANA, ERCOLI, LUCIA, ANDREONI, MASSIMO, D'Ettorre, G, Nicastri, E, Uccella, I, Massetti, P, Parisi, Sg, Vullo, V |
| المساهمون: | Sarmati, L, D'Ettorre, G, Nicastri, E, Ercoli, L, Uccella, I, Massetti, P, Parisi, S, Vullo, V, Andreoni, M |
| بيانات النشر: | AMER SOC MICROBIOLOGY WASHINGTON |
| سنة النشر: | 2001 |
| المجموعة: | Universitá degli Studi di Roma "Tor Vergata": ART - Archivio Istituzionale della Ricerca |
| مصطلحات موضوعية: | antiretrovirus agent, CD4 antigen, neutralizing antibody, RNA directed DNA polymerase inhibitor, antibody titer, article, cell count, clinical article, controlled study, human, Human immunodeficiency virus 1, Human immunodeficiency virus infection, immune response, phenotype, priority journal, serodiagnosi, virus inhibition, virus isolation, virus load, Adult, CD4 Lymphocyte Count, Cross-Sectional Studie, Female, HIV Antibodie, HIV Infection, HIV-1, Macrophage Inflammatory Protein-1, Male, Neutralization Test, RANTES |
| الوصف: | Antiretroviral-treated human immunodeficiency virus (HIV) type I-seropositive individuals can remain clinically stable for a long period of time with an increasing CD4 cell count irrespective of incomplete viral suppression. We evaluated the role of neutralizing antibody (NtAb) activity in the etiopathogenesis of this viro-immunological disconnection (defined as an increasing CD4(+)-cell count despite a persistent, detectable viral load during antiretroviral therapy) in 33 patients failing therapy with two analogue nucleoside reverse transcriptase inhibitors. An HIV NtAb titer of greater than or equal to1:25 was detected in specimens from 16 out of 33 (48%) patients. A significant correlation was found between NtAb titers and CD4(+)-cell counts (P = 0.001; r = 0.546) but not with HIV RNA levels in plasma. Five patients with a viro-immunological disconnection had an NtAb titer of >1:125, statistically higher than the NtAb titers for the remaining 28 patients with both virologic and immunologic failure (P < 0,0001). The HIV-specific humoral immune response could play a role during antiretroviral treatment to improve immunological function despite an incomplete suppression of viral load. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/11427434; info:eu-repo/semantics/altIdentifier/wos/WOS:000169705700026; volume:8; issue:4; firstpage:822; lastpage:824; numberofpages:3; journal:CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY; http://hdl.handle.net/2108/49453Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0034968106 |
| DOI: | 10.1128/CDLI.8.4.822-824.2001 |
| الإتاحة: | https://doi.org/10.1128/CDLI.8.4.822-824.2001Test http://hdl.handle.net/2108/49453Test |
| رقم الانضمام: | edsbas.E20B4FE3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1128/CDLI.8.4.822-824.2001 |
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