دورية أكاديمية
Outcome of congenital acute lymphoblastic leukemia treated on the Interfant-99 protocol
| العنوان: | Outcome of congenital acute lymphoblastic leukemia treated on the Interfant-99 protocol |
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| المؤلفون: | van der Linden, Marieke H., Valsecchi, Maria Grazia, De Lorenzo, Paola, Moericke, Anja, Janka, Gritta, Leblanc, Thierry M., Felice, Maria, Biondi, Andrea, Campbell Bull, Myriam, Hann, Ian, Rubnitz, Jeffrey E., Stary, Jan, Szczepanski, Tomasz, Vora, Ajay, Ferster, Alina, Hovi, Liisa, Silverman, Lewis B., Pieters, Rob |
| المصدر: | Blood |
| بيانات النشر: | Amer Soc Hematology |
| سنة النشر: | 2009 |
| المجموعة: | Universidad de Chile: Repositorio académico |
| مصطلحات موضوعية: | Oncology-Group, Prognostic-Factors, Infants, Experience, Therapy, Trial |
| الوصف: | Acute lymphoblastic leukemia (ALL) diagnosed in the first month of life (congenital ALL) is very rare. Although congenital ALL is often assumed to be fatal, no studies have been published on outcome except for case reports. The present study reports the outcome of 30 patients with congenital ALL treated with the uniform Interfant-99 protocol, a hybrid regimen combining ALL treatment with elements designed for treatment of acute myeloid leukemia. Congenital ALL was characterized by a higher white blood cell count and a strong trend for higher incidence of MLL rearrangements and CD10-negative B-lineage ALL compared with older infants. Induction failure rate was 13% and not significantly different from that in older infants (7%, P = .14), but relapse rate was significantly higher in congenital ALL patients (2-year cumulative incidence [SE] was 60.0 [9.3] vs 34.2 [2.3], P < .001). Two-year event-free survival and survival of congenital ALL patients treated with this protocol was 20% (SE 9.1%). Early death in complete remission and treatment delays resulting from toxicity were not different. The survival of 17% after last follow-up, combined with a toxicity profile comparable with that in older infants, justifies treating congenital ALL with curative intent. This trial was registered at www.clinicaltrials.gov as no. NCT 00015873, and at www.controlled-trials.com as no. ISRCTN24251487. ; KiKa Associazione Italiana Ricerca sul Cancro Regional Cod 1105 Fondazione Tettamanti and Comitato MM Verga Polish Ministry of Science and Higher Education 2 P054 095 30 Czech Ministry of Education MSM0021620813 Deutsche Krebshilfe |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | Blood, 29 October 2009 - Volume 114, Number 18; https://repositorio.uchile.cl/handle/2250/140896Test |
| DOI: | 10.1182/blood-2009-02-204214 |
| الإتاحة: | https://doi.org/10.1182/blood-2009-02-204214Test https://repositorio.uchile.cl/handle/2250/140896Test |
| حقوق: | Attribution-NonCommercial-NoDerivs 3.0 Chile ; http://creativecommons.org/licenses/by-nc-nd/3.0/clTest/ |
| رقم الانضمام: | edsbas.FBBB18E4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1182/blood-2009-02-204214 |
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