دورية أكاديمية
Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality.
| العنوان: | Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality. |
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| المؤلفون: | Nakanishi, T., Pigazzini, S., Degenhardt, F., Cordioli, M., Butler-Laporte, G., Maya-Miles, D., Bujanda, L., Bouysran, Y., Niemi, M.E., Palom, A., Ellinghaus, D., Khan, A., Martínez-Bueno, M., Rolker, S., Amitrano, S., Roade Tato, L., Fava, F., Spinner, C.D., Prati, D., Bernardo, D., Garcia, F., Darcis, G., Fernandez-Cadenas, I., Holter, J.C., Banales, J.M., Frithiof, R., Kiryluk, K., Duga, S., Asselta, R., Pereira, A.C., Romero-Gómez, M., Nafría-Jiménez, B., Hov, J.R., Migeotte, I., Renieri, A., Planas, A.M., Ludwig, K.U., Buti, M., Rahmouni, S., Alarcón-Riquelme, M.E., Schulte, E.C., Franke, A., Karlsen, T.H., Valenti, L., Zeberg, H., Richards, J.B., Ganna, A. |
| المصدر: | J. Clin. Invest. 131:e152386 (2021) |
| بيانات النشر: | Amer Soc Clinical Investigation Inc |
| سنة النشر: | 2021 |
| المجموعة: | PuSH - Publikationsserver des Helmholtz Zentrums München |
| مصطلحات موضوعية: | Covid-19, Genetic Variation, Genetics |
| الوصف: | BACKGROUND: There is considerable variability in COVID-19 outcomes amongst younger adults-and some of this variation may be due to genetic predisposition. METHODS: We combined individual level data from 13,888 COVID-19 patients (N=7,185 hospitalized) from 17 cohorts in nine countries to assess the association of the major common COVID-19 genetic risk factor (chromosome 3 locus tagged by rs10490770) with mortality, COVID-19-related complications and laboratory values. We next performed meta-analyses using FinnGen and the Columbia University COVID-19 Biobank. RESULTS: We found that rs10490770 risk allele carriers experienced an increased risk of all-cause mortality (HR 1.4, 95%CI 1.2-1.7). Risk allele carriers had increased odds of several COVID-19 complications: severe respiratory failure (OR 2.1, 95%CI 1.6-2.6), venous thromboembolism (OR 1.7, 95%CI 1.2-2.4), and hepatic injury (OR 1.5, 95%CI 1.2-2.0). Risk allele carriers ≤60 years had higher odds of death or severe respiratory failure (OR 2.7, 95%CI 1.8-3.9) compared to those >60 years (OR 1.5, 95%CI 1.2-1.8, interaction-p=0.038). Amongst individuals ≤60 years who died or experienced severe respiratory failure, 32.3% were risk variant carriers, compared to 13.9% of those not experiencing these outcomes. The genetic risk improved the prediction of death or severe respiratory failure similarly to, or better than, most established clinical risk factors. CONCLUSIONS: The major common COVID-19 genetic risk factor is associated with increased risks of morbidity and mortality, which are more pronounced amongst individuals ≤60 years. The effect was similar in magnitude and more common than most established clinical risk factors, suggesting potential implications for future clinical risk management. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0021-9738 1558-8238 |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/34597274; info:eu-repo/semantics/altIdentifier/wos/WOS:000726717300012; info:eu-repo/semantics/altIdentifier/isbn/0021-9738; info:eu-repo/semantics/altIdent; https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=63183Test; urn:isbn:0021-9738; urn:issn:0021-9738; urn:issn:1558-8238 |
| DOI: | 10.1172/JCI152386 |
| الإتاحة: | https://doi.org/10.1172/JCI152386Test https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=63183Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.364ADDF8 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 00219738 15588238 |
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| DOI: | 10.1172/JCI152386 |