دورية أكاديمية
Comparison of the Performance of 6 Prognostic Signatures for Estrogen Receptor-Positive Breast Cancer: A Secondary Analysis of a Randomized Clinical Trial.
| العنوان: | Comparison of the Performance of 6 Prognostic Signatures for Estrogen Receptor-Positive Breast Cancer: A Secondary Analysis of a Randomized Clinical Trial. |
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| المؤلفون: | Sestak, I, Buus, R, Cuzick, J, Dubsky, P, Kronenwett, R, Denkert, C, Ferree, S, Sgroi, D, Schnabel, C, Baehner, FL, Mallon, E, Dowsett, M |
| المساهمون: | Buus, Richard |
| بيانات النشر: | AMER MEDICAL ASSOC |
| سنة النشر: | 2017 |
| المجموعة: | The Institute of Cancer Research (ICR): Publications Repository |
| الوصف: | IMPORTANCE: Multiple molecular signatures are available for managing estrogen receptor (ER)-positive breast cancer but with little direct comparative information to guide the patient's choice. OBJECTIVE: To conduct a within-patient comparison of the prognostic value of 6 multigene signatures in women with early ER-positive breast cancer who received endocrine therapy for 5 years. DESIGN, SETTING, AND PARTICIPANTS: This retrospective biomarker analysis included 774 postmenopausal women with ER-positive ERBB2 (formerly HER2)-negative breast cancer. This analysis was performed as a preplanned secondary study of data from the Anastrozole or Tamoxifen Alone or Combined randomized clinical trial comparing 5-year treatment with anastrozole vs tamoxifen with 10-year follow-up data. The signatures included the Oncotype Dx recurrence score, PAM50-based Prosigna risk of recurrence (ROR), Breast Cancer Index (BCI), EndoPredict (EPclin), Clinical Treatment Score, and 4-marker immunohistochemical score. Data were collected from January 2009, through April 2015. MAIN OUTCOMES AND MEASURES: The primary objective was to compare the prognostic value of these signatures in addition to the Clinical Treatment Score (nodal status, tumor size, grade, age, and endocrine treatment) for distant recurrence for 0 to 10 years and 5 to 10 years after diagnosis. Likelihood ratio (LR) statistics were used with the χ2 test and C indexes to assess the prognostic value of each signature. RESULTS: In this study of 774 postmenopausal women with ER-positive, ERBB2-negative disease (mean [SD] age, 64.1 [8.1] years), 591 (mean [SD] age, 63.4 [7.9] years) had node-negative disease. The signatures providing the most prognostic information were the ROR (hazard ratio [HR], 2.56; 95% CI, 1.96-3.35), followed by the BCI (HR, 2.46; 95% CI, 1.88-3.23) and EPclin (HR, 2.14; 95% CI, 1.71-2.68). Each provided significantly more information than the Clinical Treatment Score (HR, 1.99; 95% CI, 1.58-2.50), the recurrence score (HR, 1.69; 95% CI, 1.40-2.03), and the ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 8; application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document |
| اللغة: | English |
| تدمد: | 2374-2437 |
| العلاقة: | JAMA Oncology, 2015, 1 (1), pp. 8 - 8; https://repository.icr.ac.uk/handle/internal/973Test |
| DOI: | 10.1001/jamaoncol.2014.243 |
| الإتاحة: | https://doi.org/10.1001/jamaoncol.2014.243Test https://repository.icr.ac.uk/handle/internal/1592Test https://repository.icr.ac.uk/handle/internal/973Test |
| حقوق: | https://www.rioxx.net/licenses/all-rights-reservedTest |
| رقم الانضمام: | edsbas.98D6B92F |
| قاعدة البيانات: | BASE |
| تدمد: | 23742437 |
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| DOI: | 10.1001/jamaoncol.2014.243 |