دورية أكاديمية
Phenotypic and Genetic Characterization of Lower LDL Cholesterol and Increased Type 2 Diabetes Risk in the UK Biobank
| العنوان: | Phenotypic and Genetic Characterization of Lower LDL Cholesterol and Increased Type 2 Diabetes Risk in the UK Biobank |
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| المؤلفون: | Klimentidis, Yann C, Arora, Amit, Newell, Michelle, Zhou, Jin, Ordovas, Jose M, Renquist, Benjamin J, Wood, Alexis C |
| المساهمون: | Univ Arizona, Dept Epidemiol & Biostat, Mel & Enid Zuckerman Coll Publ Hlth, Univ Arizona, BIO5 Inst, Univ Arizona, Sch Anim & Comparat Biomed Sci |
| المصدر: | Diabetes ; 69 ; 10 ; 2194 ; 2205 ; United States |
| بيانات النشر: | AMER DIABETES ASSOC |
| سنة النشر: | 2020 |
| المجموعة: | The University of Arizona: UA Campus Repository |
| الوصف: | Although hyperlipidemia is traditionally considered a risk factor for type 2 diabetes (T2D), evidence has emerged from statin trials and candidate gene investigations suggesting that lower LDL cholesterol (LDL-C) increases T2D risk. We thus sought to more comprehensively examine the phenotypic and genotypic relationships of LDL-C with T2D. Using data from the UK Biobank, we found that levels of circulating LDL-C were negatively associated with T2D prevalence (odds ratio 0.41 [95% CI 0.39, 0.43] per mmol/L unit of LDL-C), despite positive associations of circulating LDL-C with HbA1c and BMI. We then performed the first genome-wide exploration of variants simultaneously associated with lower circulating LDL-C and increased T2D risk, using data on LDL-C from the UK Biobank (n = 431,167) and the Global Lipids Genetics Consortium (n = 188,577), and data on T2D from the Diabetes Genetics Replication and Meta-Analysis consortium (n = 898,130). We identified 31 loci associated with lower circulating LDL-C and increased T2D, capturing several potential mechanisms. Seven of these loci have previously been identified for this dual phenotype, and nine have previously been implicated in nonalcoholic fatty liver disease. These findings extend our current understanding of the higher T2D risk among individuals with low circulating LDL-C and of the underlying mechanisms, including those responsible for the diabetogenic effect of LDL-C-lowering medications. ; This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0012-1797 1939-327X |
| العلاقة: | Klimentidis, Y. C., Arora, A., Newell, M., Zhou, J., Ordovas, J. M., Renquist, B. J., & Wood, A. C. (2020). Phenotypic and genetic characterization of lower LDL-C and increased type-2 diabetes risk in the UK Biobank. Diabetes, 69(10), 2194-2205. https://doi.org/10.2337/db19-1134Test; http://hdl.handle.net/10150/648095Test; DIABETES |
| DOI: | 10.2337/db19-1134 |
| الإتاحة: | https://doi.org/10.2337/db19-1134Test http://hdl.handle.net/10150/648095Test |
| حقوق: | Copyright © 2020 by the American Diabetes Association. ; http://rightsstatements.org/vocab/InC/1.0Test/ |
| رقم الانضمام: | edsbas.A286C0F7 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 00121797 1939327X |
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| DOI: | 10.2337/db19-1134 |