دورية أكاديمية
Breast-Feeding and Childhood-Onset Type 1 Diabetes A pooled analysis of individual participant data from 43 observational studies
| العنوان: | Breast-Feeding and Childhood-Onset Type 1 Diabetes A pooled analysis of individual participant data from 43 observational studies |
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| المؤلفون: | Cardwell, CR, Stene, LC, Ludvigsson, J, Rosenbauer, J, Cinek, O, Svensson, J, Perez-Bravo, F, Memon, A, Gimeno, SG, Wadsworth, EJK, Strotmeyer, ES, Goldacre, MJ, Radon, K, Chuang, L-M, Parslow, RC, Chetwynd, A, Karavanaki, K, Brigis, G, Pozzilli, P, Urbonaite, B, Schober, E, Devoti, G, Sipetic, S, Joner, G, Ionescu-Tirgoviste, C, de Beaufort, CE, Harrild, K, Benson, V, Savilahti, E, Ponsonby, A-L, Salem, M, Rabiei, S, Patterson, CC |
| بيانات النشر: | AMER DIABETES ASSOC |
| سنة النشر: | 2012 |
| المجموعة: | The University of Melbourne: Digital Repository |
| الوصف: | OBJECTIVE: To investigate if there is a reduced risk of type 1 diabetes in children breastfed or exclusively breastfed by performing a pooled analysis with adjustment for recognized confounders. RESEARCH DESIGN AND METHODS: Relevant studies were identified from literature searches using MEDLINE, Web of Science, and EMBASE. Authors of relevant studies were asked to provide individual participant data or conduct prespecified analyses. Meta-analysis techniques were used to combine odds ratios (ORs) and investigate heterogeneity between studies. RESULTS: Data were available from 43 studies including 9,874 patients with type 1 diabetes. Overall, there was a reduction in the risk of diabetes after exclusive breast-feeding for >2 weeks (20 studies; OR = 0.75, 95% CI 0.64-0.88), the association after exclusive breast-feeding for >3 months was weaker (30 studies; OR = 0.87, 95% CI 0.75-1.00), and no association was observed after (nonexclusive) breast-feeding for >2 weeks (28 studies; OR = 0.93, 95% CI 0.81-1.07) or >3 months (29 studies; OR = 0.88, 95% CI 0.78-1.00). These associations were all subject to marked heterogeneity (I(2) = 58, 76, 54, and 68%, respectively). In studies with lower risk of bias, the reduced risk after exclusive breast-feeding for >2 weeks remained (12 studies; OR = 0.86, 95% CI 0.75-0.99), and heterogeneity was reduced (I(2) = 0%). Adjustments for potential confounders altered these estimates very little. CONCLUSIONS: The pooled analysis suggests weak protective associations between exclusive breast-feeding and type 1 diabetes risk. However, these findings are difficult to interpret because of the marked variation in effect and possible biases (particularly recall bias) inherent in the included studies. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0149-5992 1935-5548 |
| العلاقة: | pii: dc12-0438; Cardwell, C. R., Stene, L. C., Ludvigsson, J., Rosenbauer, J., Cinek, O., Svensson, J., Perez-Bravo, F., Memon, A., Gimeno, S. G., Wadsworth, E. J. K., Strotmeyer, E. S., Goldacre, M. J., Radon, K., Chuang, L. -M., Parslow, R. C., Chetwynd, A., Karavanaki, K., Brigis, G., Pozzilli, P. ,. Patterson, C. C. (2012). Breast-Feeding and Childhood-Onset Type 1 Diabetes A pooled analysis of individual participant data from 43 observational studies. DIABETES CARE, 35 (11), pp.2215-2225. https://doi.org/10.2337/dc12-0438Test.; http://hdl.handle.net/11343/265238Test |
| الإتاحة: | https://doi.org/10.2337/dc12-0438Test http://hdl.handle.net/11343/265238Test |
| حقوق: | CC BY-NC-ND ; https://creativecommons.org/licenses/by-nc-nd/4.0Test |
| رقم الانضمام: | edsbas.F08C0D44 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 01495992 19355548 |
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