دورية أكاديمية
Metastability of native proteins and the phenomenon of amyloid formation
| العنوان: | Metastability of native proteins and the phenomenon of amyloid formation |
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| المؤلفون: | Baldwin A. J., Knowles T. P. J., Tartaglia G. G., Fitzpatrick A. W., Devlin G. L., Shammas S. L., Waudby C. A., Mossuto M. F., Meehan S., Gras S. L., Christodoulou J., Anthony-Cahill S. J., Barker P. D., Vendruscolo M., Dobson C. M. |
| المساهمون: | Baldwin, A. J., Knowles, T. P. J., Tartaglia, G. G., Fitzpatrick, A. W., Devlin, G. L., Shammas, S. L., Waudby, C. A., Mossuto, M. F., Meehan, S., Gras, S. L., Christodoulou, J., Anthony-Cahill, S. J., Barker, P. D., Vendruscolo, M., Dobson, C. M. |
| بيانات النشر: | AMER CHEMICAL SOC 1155 16TH ST, NW, WASHINGTON, DC 20036 USA |
| سنة النشر: | 2011 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | Amyloid, Animal, Cattle, Entropy, Human, Protein Conformation, Protein Stability |
| الوصف: | An experimental determination of the thermodynamic stabilities of a series of amyloid fibrils reveals that this structural form is likely to be the most stable one that protein molecules can adopt even under physiological conditions. This result challenges the conventional assumption that functional forms of proteins correspond to the global minima in their free energy surfaces and suggests that living systems are conformationally as well as chemically metastable. © 2011 American Chemical Society. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/21650202; info:eu-repo/semantics/altIdentifier/wos/WOS:000295193700004; volume:133; issue:36; firstpage:14160; lastpage:14163; numberofpages:4; journal:JOURNAL OF THE AMERICAN CHEMICAL SOCIETY; http://hdl.handle.net/11573/1451766Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-80052555139 |
| DOI: | 10.1021/ja2017703 |
| الإتاحة: | https://doi.org/10.1021/ja2017703Test http://hdl.handle.net/11573/1451766Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.93377D15 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/ja2017703 |
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