التفاصيل البيبلوغرافية
| العنوان: |
Cutting Edge: The UNC93B1 Tyrosine-Based Motif Regulates Trafficking and TLR Responses via Separate Mechanisms |
| المؤلفون: |
Pelka, Karin, Phulphagar, Kshiti, Zimmermann, Jana, Stahl, Rainer, Schmid-Burgk, Jonathan L., Schmidt, Tobias, Spille, Jan-Hendrik, Labzin, Larisa I., Agrawal, Sudhir, Kandimalla, Ekambar R., Casanova, Jean-Laurent, Hornung, Veit, Marshak-Rothstein, Ann, Hoening, Stefan, Latz, Eicke |
| بيانات النشر: |
AMER ASSOC IMMUNOLOGISTS |
| سنة النشر: |
2014 |
| المجموعة: |
Cologne University: KUPS |
| مصطلحات موضوعية: |
ddc:no |
| الوصف: |
Sensing of nucleic acids by TLRs is crucial in the host defense against viruses and bacteria. Unc-93 homolog B1 (UNC93B1) regulates the trafficking of nucleic acid-sensing TLRs from the endoplasmic reticulum to endolysosomes, where the TLRs encounter their respective ligands and become activated. In this article, we show that a carboxyl-terminal tyrosine-based sorting motif (Yxx Phi) in UNC93B1 differentially regulates human nucleic acid-sensing TLRs in a receptor-and ligand-specific manner. Destruction of YxxF abolished TLR7, TLR8, and TLR9 activity toward nucleic acids in human B cells and monocytes, whereas TLR8 responses toward small molecules remained intact. YxxF in UNC93B1 influenced the subcellular localization of human UNC93B1 via both adapter protein complex (AP)1- and AP2-dependent trafficking pathways. However, loss of AP function was not causal for altered TLR responses, suggesting AP-independent functions of YxxF in UNC93B1. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
Pelka, Karin, Phulphagar, Kshiti, Zimmermann, Jana, Stahl, Rainer, Schmid-Burgk, Jonathan L., Schmidt, Tobias orcid:0000-0003-3102-3515 , Spille, Jan-Hendrik orcid:0000-0001-8493-4721 , Labzin, Larisa I., Agrawal, Sudhir, Kandimalla, Ekambar R., Casanova, Jean-Laurent orcid:0000-0002-7782-4169 , Hornung, Veit orcid:0000-0002-4150-194X , Marshak-Rothstein, Ann, Hoening, Stefan and Latz, Eicke orcid:0000-0003-1488-5666 (2014). Cutting Edge: The UNC93B1 Tyrosine-Based Motif Regulates Trafficking and TLR Responses via Separate Mechanisms. J. Immunol., 193 (7). S. 3257 - 3262. BETHESDA: AMER ASSOC IMMUNOLOGISTS. ISSN 1550-6606 |
| الإتاحة: |
https://kups.ub.uni-koeln.de/42813Test/ |
| رقم الانضمام: |
edsbas.CEBA376D |
| قاعدة البيانات: |
BASE |
