Heritability and genome-wide association analyses of sleep duration in children: The EAGLE Consortium
| العنوان: | Heritability and genome-wide association analyses of sleep duration in children: The EAGLE Consortium |
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| المؤلفون: | Marinelli, Marcella, Pappa, Irene, Bustamante, Mariona, Bonilla, Carolina, Suarez, Anna, Tiesler, Carla M, Vilor-Tejedor, Natalia, Zafarmand, Mohammad Hadi, Alvarez-Pedrerol, Mar, Andersson, Sture, Bakermans-Kranenburg, Marian J, Estivill, Xavier, Evans, David M, Flexeder, Claudia, Fons, Joan, Gonzalez, Juan R, Guxens, Monica, Huss, Anke, van IJzendoorn, Marinus H, Jaddoe, Vincent W V, Julvez, Jordi, Lahti, Jari, López-Vicente, Mónica, Lopez-Espinosa, Maria-Jose, Manz, Judith, Mileva-Seitz, Viara R, Perola, Markus, Pesonen, Anu-Katriina, Rivadeneira, Fernando, Salo, Perttu P, Shahand, Shayan, Schulz, Holger, Standl, Marie, Thiering, Elisabeth, Timpson, Nicholas J, Torrent, Maties, Uitterlinden, André G, Smith, George Davey, Estarlich, Marisa, Heinrich, Joachim, Räikkönen, Katri, Vrijkotte, Tanja G M, Tiemeier, Henning, Sunyer, Jordi, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), dIRAS RA-2 |
| المساهمون: | Child and Adolescent Psychiatry / Psychology, Research Methods and Techniques, Epidemiology, Erasmus MC other, Pediatrics, Internal Medicine, Public Health, Psychiatry, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), dIRAS RA-2, Amsterdam Cardiovascular Sciences, Amsterdam Public Health, Other Research, Public and occupational health, Epidemiology and Data Science, Amsterdam Reproduction & Development (AR&D) |
| المصدر: | Sleep 39, 1859-1869 (2016) Sleep, 39(10), 1859. Oxford University Press Sleep r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) Sleep, 39(10), 1859-1869. Oxford University Press Marinelli, M, Pappa, I, Bustamante, M, Bonilla, C, Suarez, A, Tiesler, C M, Vilor-Tejedor, N, Zafarmand, M H, Alvarez-Pedrerol, M, Andersson, S, Bakermans-Kranenburg, M J, Estivill, X, Evans, D M, Flexeder, C, Forns, J, Gonzalez, J R, Guxens, M, Huss, A, Van Ijzendoorn, M H, Jaddoe, V W V, Julvez, J, Lahti, J, López-Vicente, M, Lopez-Espinosa, M J, Manz, J, Mileva-Seitz, V R, Perola, M, Pesonen, A K, Rivadeneira, F, Salo, P P, Shahand, S, Schulz, H, Standl, M, Thiering, E, Timpson, N J, Torrent, M, Uitterlinden, A G, Smith, G D, Estarlich, M, Heinrich, J, Räikkönen, K, Vrijkotte, T G M, Tiemeier, H & Sunyer, J 2016, ' Heritability and Genome-Wide Association Analyses of Sleep Duration in Children : The EAGLE Consortium ', Sleep, vol. 39, no. 10, pp. 1859-1869 . https://doi.org/10.5665/sleep.6170Test r-FISABIO. Repositorio Institucional de Producción Científica instname Sleep, 39(10), 1859-1869. American Academy of Sleep Medicine |
| بيانات النشر: | Amer Acad Sleep Medicine, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Time Factors, Adolescent, Sleep Duration/Sleep Quality, Population, Single-nucleotide polymorphism, Genome-wide association study, Polymorphism, Single Nucleotide, White People, SNP heritability, Cohort Studies, 03 medical and health sciences, Quantitative Trait, Heritable, 0302 clinical medicine, 030225 pediatrics, Physiology (medical), Genetic variation, Humans, SNP, Medicine, Longitudinal Studies, Child, education, education.field_of_study, business.industry, Excessive sleep, Heritability, genome-wide association study (GWAS), medicine.disease, 3. Good health, pathway analysis, meta-analysis, 030104 developmental biology, Diabetes Mellitus, Type 2, Child, Preschool, Meta-analysis, Female, Neurology (clinical), Sleep, business, childhood sleep duration, Snp Heritability, Genome-wide Association Study (gwas), Childhood Sleep Duration, Pathway Analysis, Genome-Wide Association Study, Demography |
| الوصف: | STUDY OBJECTIVES: Low or excessive sleep duration has been associated with multiple outcomes, but the biology behind these associations remains elusive. Specifically, genetic studies in children are scarce. In this study, we aimed to: (1) estimate the proportion of genetic variance of sleep duration in children attributed to common single nucleotide polymorphisms (SNPs), (2) identify novel SNPs associated with sleep duration in children, and (3) investigate the genetic overlap of sleep duration in children and related metabolic and psychiatric traits.METHODS: We performed a population-based molecular genetic study, using data form the EArly Genetics and Life course Epidemiology (EAGLE) Consortium. 10,554 children of European ancestry were included in the discovery, and 1,250 children in the replication phase.RESULTS: We found evidence of significant but modest SNP heritability of sleep duration in children (SNP h(2) 0.14, 95% CI [0.05, 0.23]) using the LD score regression method. A novel region at chromosome 11q13.4 (top SNP: rs74506765, P = 2.27e-08) was associated with sleep duration in children, but this was not replicated in independent studies. Nominally significant genetic overlap was only found (rG = 0.23, P = 0.05) between sleep duration in children and type 2 diabetes in adults, supporting the hypothesis of a common pathogenic mechanism.CONCLUSIONS: The significant SNP heritability of sleep duration in children and the suggestive genetic overlap with type 2 diabetes support the search for genetic mechanisms linking sleep duration in children to multiple outcomes in health and disease. |
| وصف الملف: | application/pdf |
| اللغة: | German |
| تدمد: | 7450-6765 0161-8105 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f795254a33fee30d6df8f51886ff3089Test https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=49788Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f795254a33fee30d6df8f51886ff3089 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 74506765 01618105 |
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