Survival trends for extranodal NK/T-cell lymphoma, nasal type from different anatomical sites: a population-based study
| العنوان: | Survival trends for extranodal NK/T-cell lymphoma, nasal type from different anatomical sites: a population-based study |
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| المؤلفون: | Jianyong Li, Lingxiao Xing, Jingjing Guo, Jing Zhang, Lu He, Yi Miao, Jia Wang, Yi-Xin Zou, Xiao-Lu Tang |
| المصدر: | Ann Transl Med |
| بيانات النشر: | AME Publishing Company, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Nasal cavity, medicine.medical_specialty, business.industry, General Medicine, medicine.disease, Gastroenterology, Extranodal NK/T-cell lymphoma, nasal type, Lymphoma, Population based study, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Anatomical sites, Upper aerodigestive tract, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Internal medicine, Epidemiology, Cohort, otorhinolaryngologic diseases, medicine, Original Article, business |
| الوصف: | Background Extranodal natural killer/T-cell lymphoma (NKTCL), nasal type mostly involves the upper aerodigestive tract (UAT). NKTCLs derived from the UAT are referred to as nasal NKTCLs, while those without UAT involvement are referred to as extra-nasal NKTCLs. In this study, we aimed to investigate the outcomes and survival trends of NKTCLs from different anatomical sites. Methods Data from the US Surveillance, Epidemiology, and End Results (SEER) database on NKTCL (diagnosed between 1987 and 2016) were retrospectively analyzed. Results A total of 714 patients with NKTCL were included. The median overall survival (OS) and cancer-specific survival (CSS) were 36 and 57 months, respectively. For the entire cohort, the OS was improved from era 1 to era 2 with marginal significance (P=0.0595), however, no improvement was shown in CSS. For nasal NKTCLs, the OS of patients from era 2 was significantly improved compared to that of patients from era 1 (P=0.0244). The OS was significantly improved in non-cavity nasal NKTCLs (P=0.031) but not in nasal cavity NKTCLs (P=0.2982). Significant improvements in OS (P=0.0025) and CSS (P=0.0176) were found in stage I/II non-cavity nasal NKTCLs. For patients with extra-nasal NKTCLs, no difference was found in survival outcomes between the 2 eras. Conclusions We have demonstrated that the outcomes of non-cavity nasal NKTCLs, especially those in stage I/II, have improved in the new era, while the outcomes of nasal cavity NKTCLs and extra-nasal NKTCLs have not improved. Our study highlights the heterogeneity in clinical outcomes and biology among NKTCLs from different sites. More studies are warranted to define the optimal treatments for patients with NKTCLs. |
| تدمد: | 2305-5847 2305-5839 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdfeb69238fabf3602e0645878e1167aTest https://doi.org/10.21037/atm-21-1748Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cdfeb69238fabf3602e0645878e1167a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23055847 23055839 |
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