دورية أكاديمية
Expression, activity and pharmacokinetic impact of ocular transporters
| العنوان: | Expression, activity and pharmacokinetic impact of ocular transporters |
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| المؤلفون: | Vellonen, Kati-Sisko, Hellinen, Laura, Mannermaa, Eliisa, Ruponen, Marika, Urtti, Arto, Kidron, Heidi |
| المساهمون: | School of Pharmacy, Activities |
| بيانات النشر: | Elsevier BV Alankomaat |
| سنة النشر: | 2018 |
| المجموعة: | University of Eastern Finland: UEF Electronic Publications |
| مصطلحات موضوعية: | active transport, blood-retinal barrier, blood-aqueous barrier, conjunctiva, cornea, neural retina, pharmacogenetics |
| الوصف: | The eye is protected by several tissues that limit the permeability and entry of potentially harmful substances, but also hamper the delivery of drugs in the treatment of ocular diseases. Active transport across the ocular barriers may affect drug distribution, but the impact of drug transporters on ocular drug delivery is not well known. We have collected and critically reviewed the literature for ocular expression and activity of known drug transporters. The review concentrates on drug transporters that have been functionally characterized in ocular tissues or primary cells and on transporters for which there is available expression data at the protein level. Species differences are highlighted, since these may explain observed inconsistencies in the influence of specific transporters on drug disposition. There is variable evidence about the pharmacokinetic role of transporters in ocular tissues. The strongest evidence for the role of active transport is available for the blood-retinal barrier. We explored the role of active transport in the cornea and blood retinal barrier with pharmacokinetic simulations. The simulations show that the active transport is important only in the case of specific parameter combinations. ; final draft ; peerReviewed |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 3-22 |
| اللغة: | unknown |
| تدمد: | 0169-409X |
| العلاقة: | ADVANCED DRUG DELIVERY REVIEWS; http://dx.doi.org/10.1016/j.addr.2017.12.009Test; 126; https://erepo.uef.fi/handle/123456789/6803Test |
| الإتاحة: | https://doi.org/10.1016/j.addr.2017.12.009Test https://erepo.uef.fi/handle/123456789/6803Test |
| حقوق: | CC BY-NC-ND 4.0 ; openAccess ; © Elsevier B.V. ; https://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: | edsbas.EA97B638 |
| قاعدة البيانات: | BASE |
| تدمد: | 0169409X |
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