دورية أكاديمية
Pregnancy glucagon-like peptide 1 predicts insulin but not glucose concentrations.
| العنوان: | Pregnancy glucagon-like peptide 1 predicts insulin but not glucose concentrations. |
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| المؤلفون: | Jones, Danielle L, Petry, Clive J, Burling, Keith, Barker, Peter, Turner, Elizabeth H, Kusinski, Laura C, Meek, Claire L |
| بيانات النشر: | Springer Science and Business Media LLC //dx.doi.org/10.1007/s00592-023-02142-8 Acta Diabetol |
| سنة النشر: | 2023 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | Gestational diabetes, Incretin, Insulin secretion, Insulin sensitivity, Obesity, Adult, Female, Humans, Pregnancy, Insulin, Glucagon-Like Peptide 1, Incretins, Diabetes, Gestational, Blood Glucose, Diabetes Mellitus, Type 2, Placenta, Glucose, Gastric Inhibitory Polypeptide |
| الوصف: | Acknowledgements: The authors would like to thank all the nurses, doctors, administrative and laboratory staff in the different centres who helped recruit participants, administer the oral glucose tolerances tests, take and process the blood samples for this study. We are also grateful to the participants for taking part in this study. The incretin assays were performed by the National Institute for Health Research Core Biochemistry Assay Laboratory, Cambridge Biomedical Research Centre. The OPHELIA study was supported by a European Foundation for the Study of Diabetes—Sanofi grant for innovative measurement of diabetes outcomes and subsequently by support from the National Institute of Health Research Cambridge Biomedical Research Centre (BRC) and a National Institute of Health Research Clinical Research Network chief investigator award. The OPHELIA study was supported with staff time from the NIHR Clinical Research Network. C.L.M. is supported by the Diabetes UK Harry Keen Intermediate Clinical Fellowship (DUK-HKF 17/0005712) and a European Foundation for the Study of Diabetes—Novo Nordisk Foundation Future Leader’s Award (NNF19SA058974). ; Funder: NIHR Cambridge Biomedical Research Centre; doi: http://dx.doi.org/10.13039/501100018956Test ; AIMS: Incretin hormones glucagon-like peptide 1 (GLP-1) and gastric inhibitory peptide (GIP) cause increased insulin secretion in non-pregnant adults, but their role in pregnancy, where there are additional metabolically-active hormones from the placenta, is less clear. The aim of the present study was to assess if fasting and post-load incretin concentrations were predictive of pregnancy insulin and glucose concentrations. METHODS: Pregnant women (n = 394) with one or more risk factors for gestational diabetes were recruited at 28 weeks for a 75 g oral glucose tolerance test (OGTT). Glucose, insulin, GLP-1 and GIP were measured in the fasting state and 120 min after glucose ingestion. RESULTS: Fasting plasma GLP-1 concentrations were associated with plasma insulin ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf; text/xml |
| اللغة: | English |
| العلاقة: | https://www.repository.cam.ac.uk/handle/1810/358432Test |
| الإتاحة: | https://www.repository.cam.ac.uk/handle/1810/358432Test |
| حقوق: | Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.144784C5 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |