دورية أكاديمية
Identifying Key Drivers in the Pathogenesis of Martorell Hypertensive Ischaemic Leg Ulcer: A Comparative Analysis with Chronic Venous Leg Ulcer
| العنوان: | Identifying Key Drivers in the Pathogenesis of Martorell Hypertensive Ischaemic Leg Ulcer: A Comparative Analysis with Chronic Venous Leg Ulcer |
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| المؤلفون: | Hess, Jamila, Barysch-Bonderer, Marjam-Jeanette, Seeli, Corsin, Laube, Julia, Ghosh, Adhideb, id_orcid:0 000-0002-5160-4571, Deinsberger, Julia, Weber, Benedikt, Hafner, Jürg, Meier-Schiesser, Barbara |
| المصدر: | Acta dermato-venereologica, 104 |
| بيانات النشر: | Acta Dermato-Venereologica |
| سنة النشر: | 2024 |
| المجموعة: | ETH Zürich Research Collection |
| مصطلحات موضوعية: | Martorell hypertensive ischaemic leg ulcer, inflammation, STAC2 |
| الوصف: | Martorell hypertensive ischaemic leg ulcer (Martorell HYTILU) is a rare but significant cause of distal leg ulcers. Although hypertension and diabetes are known factors in its development, the precise pathogenesis of Martorell HYTILU remains elusive. To reach a better understanding of Martorell HYTILU, transcriptomic analysis was conducted through RNA sequencing and immunohistochemical comparison of Martorell HYTILU (n = 17) with chronic venous ulcers (n = 4) and healthy skin (n = 4). Gene expression analysis showed a marked activation of immune-related pathways in both Martorell HYTILU and chronic venous ulcers compared with healthy skin. Notably, neutrophil activity was substantially higher in Martorell HYTILU. While pathway analysis revealed a mild downregulation of several immune pathways in Martorell HYTILU compared with chronic venous ulcers, keratinization, cornification, and epidermis development were significantly upregulated in Martorell HYTILU. Additionally, STAC2, a gene encoding for a protein promoting the expression of the calcium channel Cav1.1, was significantly upregulated in Martorell HYTILU and was detected perivascularly in situ (Martorell HYTILU n = 24; chronic venous ulcers n = 9, healthy skin n = 11). The high expression of STAC2 in Martorell HYTILU suggests that increased calcium influx plays an important role in the pathogenesis of the disease. Consequently, calcium channel antagonists could be a promising treatment avenue for Martorell HYTILU. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/application/pdf |
| اللغة: | English |
| العلاقة: | http://hdl.handle.net/20.500.11850/677308Test |
| DOI: | 10.3929/ethz-b-000677308 |
| الإتاحة: | https://doi.org/20.500.11850/67730810.3929/ethz-b-00067730810.2340/actadv.v104.40090Test https://hdl.handle.net/20.500.11850/677308Test |
| حقوق: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by-nc/4.0Test/ ; Creative Commons Attribution-NonCommercial 4.0 International |
| رقم الانضمام: | edsbas.6E18E6AF |
| قاعدة البيانات: | BASE |
| DOI: | 10.3929/ethz-b-000677308 |
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