H-Bond-Directing Organocatalyst for Enantioselective [4+2] Cycloadditions via Dienamine Catalysis
| العنوان: | H-Bond-Directing Organocatalyst for Enantioselective [4+2] Cycloadditions via Dienamine Catalysis |
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| المؤلفون: | Shoulei Wang, Carles Rodríguez-Escrich, Miquel A. Pericàs |
| المصدر: | Recercat. Dipósit de la Recerca de Catalunya instname |
| بيانات النشر: | ACS Publications, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 010405 organic chemistry, Stereochemistry, Hydrogen bond, Organic Chemistry, Hydroxy group, Enantioselective synthesis, 010402 general chemistry, 01 natural sciences, Biochemistry, Cycloaddition, 0104 chemical sciences, Stereocenter, Catalysis, chemistry.chemical_compound, chemistry, Stereoselectivity, Physical and Theoretical Chemistry, Heterocyclic derivatives |
| الوصف: | An efficient, highly regio- and stereoselective [4 + 2] cycloaddition reaction to generate tetrahydropyranopyrazole frameworks has been developed. To this end, a dienamine-based catalytic strategy that relies on the H-bond-directing effect of the hydroxy group of a dinaphthylprolinol-type aminocatalyst has been used. This enables the synthesis of multifunctionalized heterocyclic derivatives with three contiguous stereocenters in good yields and excellent enantioselectivities. |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cf1eefa13ba983ce393698e88001e10Test http://hdl.handle.net/2072/226233Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5cf1eefa13ba983ce393698e88001e10 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |