يعرض 1 - 7 نتائج من 7 نتيجة بحث عن '"checkpoint kinase 2"', وقت الاستعلام: 1.36s تنقيح النتائج
  1. 1
    دورية أكاديمية
    Cinchophen induces RPA1 related DNA damage and apoptosis to impair ENS development of zebrafish.

    المؤلفون: Wang, Jing, Meng, Xinyao, Chen, Xuyong, Xiao, Jun, Yu, Xiaosi, Wu, Luyao, Li, Zejian, Chen, Ke, Zhang, Xuan, Xiong, Bo, Feng, Jiexiong

    المصدر: Ecotoxicology & Environmental Safety; Mar2024, Vol. 272, pN.PAG-N.PAG, 1p

    مصطلحات موضوعية: DNA damage, CHECKPOINT kinase 2, ENTERIC nervous system, BRACHYDANIO, ATAXIA telangiectasia

    النص الكامل

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  2. 2
    دورية أكاديمية
    Novel imidazolone derivatives as potential dual inhibitors of checkpoint kinases 1 and 2: Design, synthesis, cytotoxicity evaluation, and mechanistic insights.

    المؤلفون: Sheta, Yasmin S.1 (AUTHOR), Sarg, Marwa T.1 (AUTHOR), Abdulrahman, Fatma G.1 (AUTHOR), Nossier, Eman S.2,3 (AUTHOR), Husseiny, Ebtehal M.1 (AUTHOR) ebtehal.ouf@azhar.edu.eg

    المصدر: Bioorganic Chemistry. Aug2024, Vol. 149, pN.PAG-N.PAG. 1p.

    مصطلحات موضوعية: *KINASES, *CYTOTOXINS, *IMIDAZOPYRIDINES, *CHECKPOINT kinase 2, *NON-small-cell lung carcinoma, *PYRIMIDINES, *CHECKPOINT kinase 1


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  3. 3
    دورية أكاديمية
    The Viral SUMO–Targeted Ubiquitin Ligase ICP0 is Phosphorylated and Activated by Host Kinase Chk2.

    المؤلفون: Hembram, Dambarudhar Shiba Sankar1 (AUTHOR), Negi, Hitendra1,2 (AUTHOR), Biswas, Poulomi1 (AUTHOR), Tripathi, Vasvi1 (AUTHOR), Bhushan, Lokesh1 (AUTHOR), Shet, Divya1 (AUTHOR), Kumar, Vikas1 (AUTHOR), Das, Ranabir1 (AUTHOR) rana@ncbs.res.in

    المصدر: Journal of Molecular Biology. Mar2020, Vol. 432 Issue 7, p1952-1977. 26p.

    مصطلحات موضوعية: *UBIQUITIN, *POST-translational modification, *HERPES simplex virus, *NUCLEAR proteins, *CHECKPOINT kinase 2


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  4. 4
    دورية أكاديمية
    Planar compression of extracellular substrates induces S phase arrest via ATM-independent CHK2 activation.

    المؤلفون: Hayakawa, Kimihide1, Hirata, Hiroaki1,2, Samsonov, Mikhail3, Sokabe, Masahiro1 msokabe@med.nagoya-u.ac.jp

    المصدر: Biochemical & Biophysical Research Communications. Dec2018, Vol. 506 Issue 4, p983-989. 7p.

    مصطلحات موضوعية: *SERINE/THREONINE kinases, *ENZYME activation, *CELL proliferation, *CELL cycle, *DNA damage, *CHECKPOINT kinase 2


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  5. 5
    دورية أكاديمية
    Expression, activation and clinical relevance of CHK1 and CHK2 in metastatic high-grade serous carcinoma.

    المؤلفون: Davidson, Ben1,2 bend@medisin.uio.no, Bjørnerem, Marianne1, Holth, Arild1, Hellesylt, Ellen1, Hetland Falkenthal, Thea E.3, Flørenes, Vivi Ann1

    المصدر: Gynecologic Oncology. Jul2018, Vol. 150 Issue 1, p136-142. 7p.

    مصطلحات موضوعية: *CARCINOMA, *CANCER chemotherapy, *PROTEIN expression, *MACROPHAGES, *PROGRESSION-free survival, *CHECKPOINT kinase 2, *CHECKPOINT kinase 1


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  6. 6
    دورية أكاديمية
    Checkpoint kinase 2 (Chk2) supports sensitivity to platinum-based treatment in high grade serous ovarian cancer.

    المؤلفون: Alkema, N.G.1, Tomar, T.1, van der Zee, A.G.J.1, Everts, M.2, Meersma, G.J.2, Hollema, H.3, de Jong, S.2, van Vugt, M.A.T.M.2 m.vugt@umcg.nl, Wisman, G.B.A.1 g.b.a.wisman@umcg.nl

    المصدر: Gynecologic Oncology. Jun2014, Vol. 133 Issue 3, p591-598. 8p.

    مصطلحات موضوعية: *OVARIAN cancer treatment, *CANCER chemotherapy, *DRUG resistance, *DNA damage, *ATAXIA telangiectasia, *CELLULAR signal transduction, *CHECKPOINT kinase 2


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  7. 7
    دورية أكاديمية
    Structural characterization of inhibitor complexes with checkpoint kinase 2 (Chk2), a drug target for cancer therapy

    المؤلفون: Lountos, George T.1, Jobson, Andrew G.2, Tropea, Joseph E.1, Self, Christopher R.3, Zhang, Guangtao3, Pommier, Yves2, Shoemaker, Robert H.4, Waugh, David S.1 waughd@mail.nih.gov

    المصدر: Journal of Structural Biology. Dec2011, Vol. 176 Issue 3, p292-301. 10p.

    مصطلحات موضوعية: *DRUG target, *CANCER treatment, *ENZYME inhibitors, *CELL division, *FORKHEAD transcription factors, *ATAXIA telangiectasia, *ADENOSINE triphosphatase, *ADENOSINE diphosphate, *P53 antioncogene, *CHECKPOINT kinase 2


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