التفاصيل البيبلوغرافية
| العنوان: |
DNA methylation profiles in African American prostate cancer patients in relation to disease progression. |
| المؤلفون: |
Rubicz, Rohina1 rrubicz@fredhutch.org, Zhao, Shanshan1, Geybels, Milan1, Wright, Jonathan L.1, Kolb, Suzanne1, Klotzle, Brandy1, Bibikova, Marina1, Troyer, Dean1, Lance, Raymond1, Ostrander, Elaine A.1, Feng, Ziding1, Fan, Jian-Bing1, Stanford, Janet L.1 |
| المصدر: |
Genomics. Jan2019, Vol. 111 Issue 1, p10-16. 7p. |
| مصطلحات موضوعية: |
*DNA methylation, *AFRICAN Americans, *PROSTATE cancer, *DISEASE progression, *PROSTATECTOMY |
| مستخلص: |
Abstract This study examined whether differential DNA methylation is associated with clinical features of more aggressive disease at diagnosis and prostate cancer recurrence in African American men, who are more likely to die from prostate cancer than other populations. Tumor tissues from 76 African Americans diagnosed with prostate cancer who had radical prostatectomy as their primary treatment were profiled for epigenome-wide DNA methylation levels. Long-term follow-up identified 19 patients with prostate cancer recurrence. Twenty-three CpGs were differentially methylated (FDR q ≤ 0.25, mean methylation difference ≥ 0.10) in patients with vs. without recurrence, including CpGs in GCK , CDKL2 , PRDM13 , and ZFR2. Methylation differences were also observed between men with metastatic-lethal prostate cancer vs. no recurrence (five CpGs), regional vs. local pathological stage (two CpGs), and higher vs. lower tumor aggressiveness (one CpG). These results indicate that differentially methylated CpG sites identified in tumor tissues of African American men may contribute to prostate cancer aggressiveness. Highlights • Tumor DNA methylation is profiled in African American prostate cancer patients. • Differentially methylated CpGs are identified for more aggressive disease features. • CpG methylation level in GCK , CDKL2 , PRDM13 , and ZFR2 is associated with recurrence. • DNA methylation status is associated with altered mRNA level for several genes. • Results may advance knowledge of tumor aggressiveness in African American patients. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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