التفاصيل البيبلوغرافية
| العنوان: |
A novel long non-coding RNA PCLN16 facilitates androgen receptor signaling in prostate cancer. |
| المؤلفون: |
Shi, Zhenfeng1 (AUTHOR), Chen, Jie2 (AUTHOR), Wumaner, Aikebaier1 (AUTHOR), Li, Ming1 (AUTHOR), Liang, Chengyuan3 (AUTHOR), Li, Min1,4 (AUTHOR) medlm_grace@yeah.net |
| المصدر: |
Biochemical & Biophysical Research Communications. Jan2021, Vol. 537, p78-84. 7p. |
| مصطلحات موضوعية: |
*LINCRNA, *PROSTATE cancer, *ANDROGEN receptors, *HUNTINGTIN protein, *EXOCRINE glands, *CANCER invasiveness, *MEN'S health |
| مستخلص: |
The prostate cancer (PCa) poses serious threat to men's health. The androgen receptor (AR) is essential for normal prostate development and prostate cancer progression. We identified a novel lncRNA PCLN16 which is significantly correlated with AR signaling during prostate cancer progression. The AR-regulated PCLN16 was abundantly overexpressed in localized or metastatic prostate cancer tissues and AR-dependent cell lines. PCLN16 silence suppressed AR signaling and tumor growth. PCLN16 interacted with Huntingtin interacting protein 1 (HIP1) transcript to reduce HIP1 degradation. Therefore, PCLN16 could augment AR signaling via a novel positive feedback loop. Our experiments support an oncogenic role for PCLN16 and suggest that PCLN16 might serve as a potential target for therapeutic intervention. • AR-regulated PCLN16 was abundantly overexpressed in prostate cancer. • PCLN16 interacted with HIP1 transcript to reduce HIP1 degradation. • PCLN16 could augment AR signaling via a novel positive feedback loop. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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