التفاصيل البيبلوغرافية
| العنوان: |
IL-6 is present in beta and alpha cells in human pancreatic islets: Expression is reduced in subjects with type 1 diabetes. |
| المؤلفون: |
Rajendran, Sakthi1 (AUTHOR), Anquetil, Florence1 (AUTHOR), Quesada-Masachs, Estefania1 (AUTHOR), Graef, Madeleine1 (AUTHOR), Gonzalez, Nathaly1 (AUTHOR), McArdle, Sara1 (AUTHOR), Chu, Tiffany1 (AUTHOR), Krogvold, Lars2,3 (AUTHOR), Dahl-Jørgensen, Knut2,4 (AUTHOR), von Herrath, Matthias1 (AUTHOR) matthias@lji.org |
| المصدر: |
Clinical Immunology. Feb2020, Vol. 211, pN.PAG-N.PAG. 1p. |
| مصطلحات موضوعية: |
*TYPE 1 diabetes, *PANCREATIC beta cells, *ISLANDS of Langerhans, *INSULINOMA, *BETA functions, *AUTOIMMUNE diseases |
| مستخلص: |
IL-6 is a pro-inflammatory cytokine upregulated in some autoimmune diseases. The role of IL-6 in the development of type 1 diabetes (T1D) is unclear. Clinical studies are investigating whether tocilizumab (anti-IL-6 receptor) can help preserve beta cell function in patients recently diagnosed with T1D. However, in some rodent models and isolated human islets, IL-6 has been found to have a protective role for beta cells by reducing oxidative stress. Hence, we systematically investigated local tissue expression of IL-6 in human pancreas from non-diabetic, auto-antibody positive donors and donors with T1D and T2D. IL-6 was constitutively expressed by beta and alpha cells regardless of the disease state. However, expression of IL-6 was highly reduced in insulin-deficient islets of donors with T1D, and the expression was then mostly restricted to alpha cells. Our findings suggest that the implication of IL-6 in T1D pathogenesis might be more complex than previously assumed. • IL-6 is expressed on human pancreatic beta and alpha cells. • Beta cells are the source of majority of IL-6 in pancreatic islets. • IL-6 expression is reduced in islets of donors with type 1 diabetes, particularly in insulin-deficient islets. • IL-6 is secreted by live human islet cultures and increased upon metabolic and immune stress. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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