التفاصيل البيبلوغرافية
| العنوان: |
Investigation of citrinin and monacolin K gene clusters variation among pigment producer Monascus species. |
| المؤلفون: |
Liu, Anan1 (AUTHOR), Juan Chen, Amanda2 (AUTHOR), Liu, Bingyu1 (AUTHOR), Wei, Qian1 (AUTHOR), Bai, Jian1 (AUTHOR), Hu, Youcai1 (AUTHOR) huyoucai@imm.ac.cn |
| المصدر: |
Fungal Genetics & Biology. May2022, Vol. 160, pN.PAG-N.PAG. 1p. |
| مصطلحات موضوعية: |
*GENE clusters, *MONASCUS, *CITRININ, *SPECIES, *FILAMENTOUS fungi, *PIGMENTS, *COLORING matter in food |
| مستخلص: |
[Display omitted] • The genus Monascus can be delimited into three sections. • Each section has a specialized secondary metabolic gene cluster composition. • Sections A and B produce citrinin and monacolin K respectively. • Monascus sanguineus is genetically incapable of producing citrinin and monacolin K. • Monascus secondary metabolism gene clusters have undergone significant gene loss. The filamentous fungi Monascus spp. have been widely used in the production of food colorants. However, the presence of mycotoxin citrinin and the antihypercholestrolemia agent monacolin K in Monascus -fermented products (MFPs) has raised food safety concerns. Here we de novo -sequenced the genomes of 26 Monascus species and proposed an unprecedented classification system, consist of sections A, B and C, according to the biosynthetic gene clusters (BGCs) distribution and phylogeny results. Based on the absence of citrinin gene cluster, section B species were genetically incapable of synthesizing citrinin. A distinguished section A strain named Monascus sanguineus was believed to be a promising food-pigment-producer particularly owing to the simultaneous inactivation of citrinin and monacolin K clusters. Interestingly, gene losses within Monascus secondary metabolism gene clusters were broadly discovered, which may convey a selective advantage in nutrients and energy competition to support the strong pigment-producing ability. Overall, our sectional delimitation system will reshape the industrial strategies for this economically important fungus. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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